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Plasma Extracellular MicroRNAs Associated With Cardiovascular Disease Risk Factors in Middle-Aged and Older Adults.
Karlin, Hannah; Sooda, Meera; Larson, Martin; Rong, Jian; Huan, Tianxiao; Mens, Michelle M J; van Rooij, Frank J A; Ikram, M Arfan; Courchesne, Paul; Freedman, Jane E; Joehanes, Roby; Mueller, Gregory P; Kavousi, Maryam; Ghanbari, Mohsen; Levy, Daniel.
Afiliación
  • Karlin H; Framingham Heart Study Framingham MA USA.
  • Sooda M; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA.
  • Larson M; Framingham Heart Study Framingham MA USA.
  • Rong J; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA.
  • Huan T; Framingham Heart Study Framingham MA USA.
  • Mens MMJ; Department of Biostatistics Boston University School of Public Health Boston MA USA.
  • van Rooij FJA; Framingham Heart Study Framingham MA USA.
  • Ikram MA; Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston MA USA.
  • Courchesne P; Framingham Heart Study Framingham MA USA.
  • Freedman JE; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA.
  • Joehanes R; Ophthalmology and Visual Sciences University of Massachusetts Medical School Worcester MA USA.
  • Mueller GP; Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands.
  • Kavousi M; Department of Social and Behavioral Sciences Harvard T.H Chan School of Public Health Boston MA USA.
  • Ghanbari M; Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands.
  • Levy D; Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands.
J Am Heart Assoc ; 13(12): e033674, 2024 Jun 18.
Article en En | MEDLINE | ID: mdl-38860398
ABSTRACT

BACKGROUND:

Extracellular microRNAs (miRNAs) are a class of noncoding RNAs that remain stable in the extracellular milieu, where they contribute to various physiological and pathological processes by facilitating intercellular signaling. Previous studies have reported associations between miRNAs and cardiovascular diseases (CVDs); however, the plasma miRNA signatures of CVD and its risk factors have not been fully elucidated at the population level. METHODS AND

RESULTS:

Plasma miRNA levels were measured in 4440 FHS (Framingham Heart Study) participants. Linear regression analyses were conducted to test the cross-sectional associations of each miRNA with 8 CVD risk factors. Prospective analyses of the associations of miRNAs with new-onset obesity, hypertension, type 2 diabetes, CVD, and all-cause mortality were conducted using proportional hazards regression. Replication was carried out in 1999 RS (Rotterdam Study) participants. Pathway enrichment analyses were conducted and target genes were predicted for miRNAs associated with ≥5 risk factors in the FHS. In the FHS, 6 miRNAs (miR-193b-3p, miR-122-5p, miR-365a-3p, miR-194-5p, miR-192-5p, and miR-193a-5p) were associated with ≥5 risk factors. This miRNA signature was enriched for pathways associated with CVD and several genes annotated to these pathways were predicted targets of the identified miRNAs. Furthermore, miR-193b-3p, miR-194-5p, and miR-193a-5p were each associated with ≥2 risk factors in the RS. Prospective analysis revealed 8 miRNAs associated with all-cause mortality in the FHS.

CONCLUSIONS:

These findings highlight associations between miRNAs and CVD risk factors that may provide valuable insights into the underlying pathogenesis of CVD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / MicroARNs / Factores de Riesgo de Enfermedad Cardiaca Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / MicroARNs / Factores de Riesgo de Enfermedad Cardiaca Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido