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A somatic genetic clock for clonal species.
Yu, Lei; Renton, Jessie; Burian, Agata; Khachaturyan, Marina; Bayer, Till; Kotta, Jonne; Stachowicz, John J; DuBois, Katherine; Baums, Iliana B; Werner, Benjamin; Reusch, Thorsten B H.
Afiliación
  • Yu L; GEOMAR Helmholtz-Center for Ocean Research Kiel, Marine Evolutionary Ecology, Kiel, Germany.
  • Renton J; Evolutionary Dynamics Group, Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
  • Burian A; Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, Katowice, Poland.
  • Khachaturyan M; GEOMAR Helmholtz-Center for Ocean Research Kiel, Marine Evolutionary Ecology, Kiel, Germany.
  • Bayer T; Institute of General Microbiology, Kiel University, Kiel, Germany.
  • Kotta J; GEOMAR Helmholtz-Center for Ocean Research Kiel, Marine Evolutionary Ecology, Kiel, Germany.
  • Stachowicz JJ; Estonian Marine Institute, University of Tartu, Tallinn, Estonia.
  • DuBois K; Department of Evolution and Ecology, University of California, Davis, CA, USA.
  • Baums IB; Department of Evolution and Ecology, University of California, Davis, CA, USA.
  • Werner B; Helmholtz Institute for Functional Marine Biodiversity, University of Oldenburg, Oldenburg, Germany.
  • Reusch TBH; Alfred Wegener Institute, Helmholtz-Centre for Polar and Marine Research (AWI), Bremerhaven, Germany.
Nat Ecol Evol ; 8(7): 1327-1336, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38858515
ABSTRACT
Age and longevity are key parameters for demography and life-history evolution of organisms. In clonal species, a widespread life history among animals, plants, macroalgae and fungi, the sexually produced offspring (genet) grows indeterminately by producing iterative modules, or ramets, and so obscure their age. Here we present a novel molecular clock based on the accumulation of fixed somatic genetic variation that segregates among ramets. Using a stochastic model, we demonstrate that the accumulation of fixed somatic genetic variation will approach linearity after a lag phase, and is determined by the mitotic mutation rate, without direct dependence on asexual generation time. The lag phase decreased with lower stem cell population size, number of founder cells for the formation of new modules, and the ratio of symmetric versus asymmetric cell divisions. We calibrated the somatic genetic clock on cultivated eelgrass Zostera marina genets (4 and 17 years respectively). In a global data set of 20 eelgrass populations, genet ages were up to 1,403 years. The somatic genetic clock is applicable to any multicellular clonal species where the number of founder cells is small, opening novel research avenues to study longevity and, hence, demography and population dynamics of clonal species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción Asexuada Idioma: En Revista: Nat Ecol Evol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción Asexuada Idioma: En Revista: Nat Ecol Evol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido