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The Fetal Spleen in Low-Risk Pregnancies and prior to Preterm Birth: Observational Study of the Role of Anatomical and Functional Magnetic Resonance Imaging.
Hall, Megan; Uus, Alena; Preston, Megan; Suff, Natalie; Gibbons, Deena; Rutherford, Mary; Shennan, Andrew; Hutter, Jana; Story, Lisa.
Afiliación
  • Hall M; Department of Women and Children's Health, St Thomas' Hospital, King's College London, London, UK.
  • Uus A; Department of Perinatal Imaging, St Thomas' Hospital, King's College London, London, UK.
  • Preston M; Department of Women and Children's Health, St Thomas' Hospital, King's College London, London, UK.
  • Suff N; Department of Women and Children's Health, St Thomas' Hospital, King's College London, London, UK.
  • Gibbons D; Department of Women and Children's Health, St Thomas' Hospital, King's College London, London, UK.
  • Rutherford M; Peter Gorer Department of Immunobiology, Guy's Hospital, King's College London, London, UK.
  • Shennan A; Department of Perinatal Imaging, St Thomas' Hospital, King's College London, London, UK.
  • Hutter J; Department of Women and Children's Health, St Thomas' Hospital, King's College London, London, UK.
  • Story L; Department of Perinatal Imaging, St Thomas' Hospital, King's College London, London, UK.
Fetal Diagn Ther ; 51(5): 419-431, 2024.
Article en En | MEDLINE | ID: mdl-38857593
ABSTRACT

INTRODUCTION:

Spontaneous preterm birth complicates ∼7% of pregnancies and causes morbidity and mortality. Although infection is a common etiology, our understanding of the fetal immune system in vivo is limited. This study aimed to utilize T2-weighted imaging and T2* relaxometry (which is a proxy of tissue oxygenation) of the fetal spleen in uncomplicated pregnancies and in fetuses that were subsequently delivered spontaneously prior to 32 weeks.

METHODS:

Women underwent imaging including T2-weighted fetal body images and multi-eco gradient echo single-shot echo planar sequences on a Phillips Achieva 3T system. Previously described postprocessing techniques were applied to obtain T2- and T2*-weighted imaging of the fetal spleen and T2-weighted fetal body volumes.

RESULTS:

Among 55 women with uncomplicated pregnancies, an increase in fetal splenic volume, splenicbody volume, and a decrease in splenic T2* signal intensity was demonstrated across gestation. Compared to controls, fetuses who were subsequently delivered prior to 32 weeks' gestation (n = 19) had a larger spleen when controlled for the overall size of the fetus (p = 0.027), but T2* was consistent (p = 0.76).

CONCLUSION:

These findings provide evidence of a replicable method of studying the fetal immune system and give novel results on the impact of impending preterm birth on the spleen. While T2* decreases prior to preterm birth in other organs, preservation demonstrated here suggests preferential sparing of the spleen.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bazo / Imagen por Resonancia Magnética / Nacimiento Prematuro Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Fetal Diagn Ther Asunto de la revista: DIAGNOSTICO POR IMAGEM / OBSTETRICIA / PERINATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bazo / Imagen por Resonancia Magnética / Nacimiento Prematuro Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Fetal Diagn Ther Asunto de la revista: DIAGNOSTICO POR IMAGEM / OBSTETRICIA / PERINATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza