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Longitudinal Assessment of Glymphatic Changes Following Mild Traumatic Brain Injury: Insights from PVS burden and DTI-ALPS Imaging.
Zhuo, Jiachen; Raghavan, Prashant; Jiang, Li; Roys, Steven; Tchoquessi, Rosy Linda Njonkou; Chen, Hegang; Wickwire, Emerson M; Parikh, Gunjan Y; Schwartzbauer, Gary T; Grattan, Lynn M; Wang, Ze; Gullapalli, Rao P; Badjatia, Neeraj.
Afiliación
  • Zhuo J; Center for Advanced Imaging Research, University of Maryland School of Medicine, Baltimore, MD.
  • Raghavan P; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD.
  • Jiang L; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD.
  • Roys S; Center for Advanced Imaging Research, University of Maryland School of Medicine, Baltimore, MD.
  • Tchoquessi RLN; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD.
  • Chen H; Center for Advanced Imaging Research, University of Maryland School of Medicine, Baltimore, MD.
  • Wickwire EM; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD.
  • Parikh GY; Center for Advanced Imaging Research, University of Maryland School of Medicine, Baltimore, MD.
  • Schwartzbauer GT; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD.
  • Grattan LM; Department of Epidemiology & public Health, University of Maryland School of Medicine, Baltimore, MD.
  • Wang Z; Department of Psychiatry & Medicine, University of Maryland School of Medicine, Baltimore, MD.
  • Gullapalli RP; Program in Trauma, University of Maryland School of Medicine, Baltimore, MD.
  • Badjatia N; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD.
medRxiv ; 2024 Jun 02.
Article en En | MEDLINE | ID: mdl-38854000
ABSTRACT
Traumatic brain injury (TBI) even in the mild form may result in long-lasting post-concussion symptoms. TBI is also a known risk to late-life neurodegeneration. Recent studies suggest that dysfunction in the glymphatic system, responsible for clearing protein waste from the brain, may play a pivotal role in the development of dementia following TBI. Given the diverse nature of TBI, longitudinal investigations are essential to comprehending the dynamic changes in the glymphatic system and its implications for recovery. In this prospective study, we evaluated two promising glymphatic imaging markers, namely the enlarged perivascular space (ePVS) burden and Diffusion Tensor Imaging-based ALPS index, in 44 patients with mTBI at two early post-injury time points approximately 14 days (14Day) and 6-12 months (6-12Mon) post-injury, while also examining their associations with post-concussion symptoms. Additionally, 37 controls, comprising both orthopedic patients and healthy individuals, were included for comparative analysis. Our key findings include 1) White matter ePVS burden (WM-ePVS) and ALPS index exhibit significant correlations with age. 2) Elevated WM-ePVS burden in acute mTBI (14Day) is significantly linked to a higher number of post-concussion symptoms, particularly memory problems. 3) The increase in the ALPS index from acute (14Day) to the chronic (6-12Mon) phases in mTBI patients correlates with improvement in sleep measures. Furthermore, incorporating WM-ePVS burden and the ALPS index from acute phase enhances the prediction of chronic memory problems beyond socio-demographic and basic clinical information, highlighting their distinct roles in assessing glymphatic structure and activity. Early evaluation of glymphatic function could be crucial for understanding TBI recovery and developing targeted interventions to improve patient outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos