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Racial Differences in Age-Related Changes in Left Ventricular Structural and Functional Echocardiographic Measurements Among Healthy Japanese and American Participants　- A Subanalysis of the World Alliance Society of Echocardiography Normal Values Study.
Nakao, Tomoko; Nakanishi, Koki; Sawada, Naoko; Kawahara, Takuya; Miyoshi, Tatuya; Takeuchi, Masaaki; Asch, Federico M; Lang, Roberto M; Daimon, Masao.
Afiliación
  • Nakao T; Department of Clinical Laboratory, The University of Tokyo Hospital.
  • Nakanishi K; Department of Cardiovascular Medicine, The University of Tokyo Hospital.
  • Sawada N; Department of Cardiovascular Medicine, The University of Tokyo Hospital.
  • Kawahara T; Department of Cardiovascular Medicine, The University of Tokyo Hospital.
  • Miyoshi T; Department of Cardiology, NTT Medical Center Tokyo.
  • Takeuchi M; Clinical Research Promotion Center, The University of Tokyo Hospital.
  • Asch FM; Department of Cardiology, Faculty of Medicine, Kindai University.
  • Lang RM; MedStar Health Research Institute.
  • Daimon M; Department of Laboratory and Transfusion Medicine, Hospital of University of Occupational and Environmental Health, School of Medicine.
Circ J ; 88(9): 1461-1471, 2024 Aug 23.
Article en En | MEDLINE | ID: mdl-38852997
ABSTRACT

BACKGROUND:

Age-related changes in left ventricular (LV) structure and function lower the threshold for the onset of heart failure with preserved ejection fraction (HFpEF). LV parameters change also with race; however, the racial differences in age-related changes in LV parameters with and without adjustment for body mass index (BMI), heart rate (HR), and blood pressure (BP) remain unclear. METHODS AND

RESULTS:

We performed a subanalysis of the World Alliance Society of Echocardiography Normal Values Study, an international cross-sectional study that examined normal echocardiographic values in 15 countries. The age-related changes in 2-dimensional echocardiographic derived parameters including LV size, systolic function, and mass, were compared between healthy Japanese (n=227) and healthy White (n=98) and Black (n=69) American participants. In men, age-related changes in all parameters did not differ significantly among races. However, compared with Japanese women, White American women had a smaller body surface area (BSA)-indexed LV volume, BSA-indexed LV internal dimension at end-systole, BSA-indexed LV stroke volume, and LV mass index to BSA, and a larger LV ejection fraction with age, even after adjusting for BMI, HR, and BP.

CONCLUSIONS:

Age-related changes in LV structure and function, which are important for the pathophysiology of HFpEF, may differ by race. Therefore, future studies examining echocardiographic reference values for each age group in each race are needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ecocardiografía / Función Ventricular Izquierda / Ventrículos Cardíacos Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Asia Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ecocardiografía / Función Ventricular Izquierda / Ventrículos Cardíacos Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Asia Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón