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Adrenocortical tumor manifesting as virilizing in a female child: Adenoma or carcinoma? A rare case report.
Breim, Fatima; Jaweesh, Amal; Sleibi, Amir; Kanaa, Lama; Sattout, Hanin; Morjan, Mohamad.
Afiliación
  • Breim F; Faculty of Medicine, University of Aleppo, Aleppo, Syria. Electronic address: fatmehbrim@gmail.com.
  • Jaweesh A; Faculty of Medicine, University of Aleppo, Aleppo, Syria.
  • Sleibi A; Faculty of Medicine, University of Aleppo, Aleppo, Syria.
  • Kanaa L; Faculty of Medicine, University of Aleppo, Aleppo, Syria.
  • Sattout H; Department of Endocrinology, Faculty of Medicine, University of Aleppo, Aleppo, Syria.
  • Morjan M; Department of Pediatric Surgery, Faculty of Medicine, University of Aleppo, Aleppo, Syria. Electronic address: mohamad_morjan@alepuniv.edu.sy.
Int J Surg Case Rep ; 120: 109878, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38852562
ABSTRACT

INTRODUCTION:

Adrenocortical tumors (ACTs) are rare endocrine neoplasms in children, with functional ACTs being more prevalent than non-functional types. Clinical manifestations typically include virilization, Cushing's syndrome, and hyperaldosteronism. Surgical intervention is the primary treatment for ACTs, with a significant risk of recurrence in adrenocortical carcinoma even after complete resection. PRESENTATION OF CASE This case presentation describes a 3.5-year-old female with generalized hirsutism and clitoral hypertrophy, leading to the discovery of a left adrenal tumor. The child underwent adrenalectomy, revealing a benign adrenal cortical adenoma. Unfortunately, due to loss of follow-up, the child later presented with pulmonary metastases and passed away, preventing further investigation into the source of metastases.

DISCUSSION:

Adrenocortical tumors are uncommon in children, with the classification of ACTs into adenomas and carcinomas. To our knowledge, this is the third case of an adrenocortical tumor in a child in Syria. We highlight the challenges in managing pediatric ACTs and emphasize the importance of timely intervention and close monitoring to improve outcomes. Regular follow-up is crucial to detect complications early and optimize treatment strategies, especially considering the unpredictable behavior of these tumors.

CONCLUSION:

This case confirms that distinguishing between adrenocortical adenoma and carcinoma can be challenging even histologically. Therefore, it is necessary to follow up after treating each case of adenoma in a child to prevent major complications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Surg Case Rep Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Surg Case Rep Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos