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Whole-transcriptome sequencing and bioinformatics analysis of calcified outer-layer tissue from cystic echinococcosis.
Wang, S B; Sun, H H; Ma, Y B; Dai, Y; Ren, Q; Liu, Y Q; Shi, C H; Toa, J; Li, J.
Afiliación
  • Wang SB; Orthopaedic Center of the First Affiliated Hospital of Shihezi University, Shihezi 832000, Xinjiang, China.
  • Sun HH; Laboratory of Translational Medicine, School of Medicine, Shihezi University, Shihezi 832000, Xinjiang, China.
  • Ma YB; Laboratory of Translational Medicine, School of Medicine, Shihezi University, Shihezi 832000, Xinjiang, China.
  • Dai Y; Orthopaedic Center of the First Affiliated Hospital of Shihezi University, Shihezi 832000, Xinjiang, China.
  • Ren Q; Laboratory of Translational Medicine, School of Medicine, Shihezi University, Shihezi 832000, Xinjiang, China.
  • Liu YQ; Laboratory of Translational Medicine, School of Medicine, Shihezi University, Shihezi 832000, Xinjiang, China.
  • Shi CH; Orthopaedic Center of the First Affiliated Hospital of Shihezi University, Shihezi 832000, Xinjiang, China.
  • Toa J; Department of joint surgery, Shihezi people's Hospital, Shihezi 832000, Xinjiang, China.
  • Li J; Orthopaedic Center of the First Affiliated Hospital of Shihezi University, Shihezi 832000, Xinjiang, China.
Trop Biomed ; 41(1): 20-28, 2024 Mar 01.
Article en En | MEDLINE | ID: mdl-38852130
ABSTRACT
Echinococcosis is a common zoonotic disease in livestock; the type with the highest incidence is cystic echinococcosis (CE). In clinical management, patients with CE of the liver in which the cyst wall is calcified have been found to have better prognoses than those without calcification. In this study, we collected calcified and uncalcified cyst wall tissue from patients with hepatic CE and observed significant changes in the expression of 2336 messenger ribonucleic acids (mRNAs), 178 long noncoding RNAs (lncRNAs), 210 microRNAs (miRNAs), and 33 circular RNAs (circRNAs) using high-throughput sequencing (HTS). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of differentially expressed RNAs (DERNAs DEmRNAs, DElncRNAs, DEmiRNAs, and DEcircRNAs) were performed to explore these RNAs' potential biological functions and signaling pathways. Ultimately, the results of hematoxylin and eosin (H&E) and terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) staining confirmed the correlation between calcification and apoptosis of the cyst wall. In summary, this study was an initial exploration of the molecular-biological mechanism underlying spontaneous calcification of the hydatid cyst wall, and it provides a theoretical basis for exploring new targets for drug treatment in CE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biología Computacional Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Trop Biomed Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Malasia
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biología Computacional Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Trop Biomed Asunto de la revista: MEDICINA TROPICAL / PARASITOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Malasia