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Mast cell activation syndrome: Current understanding and research needs.
Castells, Mariana; Giannetti, Matthew P; Hamilton, Matthew J; Novak, Peter; Pozdnyakova, Olga; Nicoloro-SantaBarbara, Jennifer; Jennings, Susan V; Francomano, Clair; Kim, Brian; Glover, Sarah C; Galli, Stephen J; Maitland, Anne; White, Andrew; Abonia, J Pablo; Slee, Valerie; Valent, Peter; Butterfield, Joseph H; Carter, Melody; Metcalfe, Dean D; Akin, Cem; Lyons, Jonathan J; Togias, Alkis; Wheatley, Lisa; Milner, Joshua D.
Afiliación
  • Castells M; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass. Electronic address: mcastells@bwh.harvard.edu.
  • Giannetti MP; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
  • Hamilton MJ; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
  • Novak P; Department of Neurology, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
  • Pozdnyakova O; department of Pathology, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
  • Nicoloro-SantaBarbara J; department of Psychiatry, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
  • Jennings SV; The Mast Cell Disease Society Inc, Sterling, Mass.
  • Francomano C; Medical and Molecular Genetics, Riley Children's Health, Indianapolis, Ind.
  • Kim B; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Glover SC; Gastroenterology & Hepatology, Tulane University School of Medicine, New Orleans, La.
  • Galli SJ; Departments of Pathology and Immunology and Microbiology, and the Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, Calif.
  • Maitland A; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; Allergy and Immunology Services, Metrodora Institute, Salt Lake City, Utah.
  • White A; Division of Allergy and Immunology, Scripps Clinic, San Diego, Calif.
  • Abonia JP; Departent of Pediatrics, Cincinnati Children's Hospital, Cincinnati, Ohio.
  • Slee V; The Mast Cell Disease Society Inc, Sterling, Mass.
  • Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
  • Butterfield JH; Division of Allergic Diseases and the Mayo Clinic Program for Mast Cell and Eosinophilic Disorders, Mayo Clinic, Rochester, Minn.
  • Carter M; Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
  • Metcalfe DD; Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
  • Akin C; Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Mich.
  • Lyons JJ; Division of Allergy and Immunology, Department of Medicine, University of California-San Diego, La Jolla, Calif; Veterans Affairs San Diego Healthcare System, La Jolla, Calif.
  • Togias A; Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
  • Wheatley L; Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
  • Milner JD; Division of Pediatric Allergy, Immunology and Rheumatology, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY.
J Allergy Clin Immunol ; 154(2): 255-263, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38851398
ABSTRACT
Mast cell activation syndrome (MCAS) is a term applied to several clinical entities that have gained increased attention from patients and medical providers. Although several descriptive publications about MCAS exist, there are many gaps in knowledge, resulting in confusion about this clinical syndrome. Whether MCAS is a primary syndrome or exists as a constellation of symptoms in the context of known inflammatory, allergic, or clonal disorders associated with systemic mast cell activation is not well understood. More importantly, the underlying mechanisms and pathways that lead to mast cell activation in MCAS patients remain to be elucidated. Here we summarize the known literature, identify gaps in knowledge, and highlight research needs. Covered topics include contextualization of MCAS and MCAS-like endotypes and related diagnostic evaluations; mechanistic research; management of typical and refractory symptoms; and MCAS-specific education for patients and health care providers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mastocitosis / Mastocitos Límite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mastocitosis / Mastocitos Límite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos