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Tell-tale immune-related neurological syndromes: Should we look for and underlying low-grade B-cell lymphoma? A retrospective study on 12 cases.
Coen, Matteo; Benyamine, Audrey; Delmont, Emilien; Kaplanski, Gilles; Bouabdallah, Reda; Xerri, Luc; Attarian, Shahram; Serratrice, Jacques.
Afiliación
  • Coen M; Division of General Internal Medicine, Department of Medicine, Hôpitaux Universitaires de Genève, Genève, Switzerland; Unit of Development and Research in Medical Education, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address: matteo.coen@hug.ch.
  • Benyamine A; Service of Internal Medicine, CHU Nord, AP-HM, Marseille, France.
  • Delmont E; Referral Centre for Neuromuscular Diseases and ALS, Hôpital La Timone, Marseille, France.
  • Kaplanski G; Department of Internal Medicine and Clinical Immunology, CHU La Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France.
  • Bouabdallah R; Department of Hematology, Hopital Privé de Provence, Aix en Provence, France.
  • Xerri L; Department of Tumor Immunology, Paoli-Calmettes Institute, Marseille, France.
  • Attarian S; Referral Centre for Neuromuscular Diseases and ALS, Hôpital La Timone, Marseille, France.
  • Serratrice J; Division of General Internal Medicine, Department of Medicine, Hôpitaux Universitaires de Genève, Genève, Switzerland.
Pathol Res Pract ; 260: 155377, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38850875
ABSTRACT

INTRODUCTION:

Immune-related neurological syndromes (affecting both the central and peripheral nervous system, as well as the neuromuscular junction) can associate with low-grade B-cell lymphomas.

METHODS:

We conducted a retrospective study on the records of patients with miscellaneous immune-related neuropathies followed by the "Referral Centre for Neuromuscular Diseases and ALS" in collaboration with the Services of Internal Medicine and Hematology (La Timone Hospital, and the Paoli Calmettes-Insitute, Marseille, France; Geneva University Hospitals, Geneva, Switzerland). Clinical, biological, immunological and histological work-up was carried out and data collected.

RESULTS:

We identified 12 patients with neurological syndromes and atypical presentation/course. In all these patients multiple autoantibodies were found. This prompted us to perform thorough hematologic investigations, that led to the diagnosis of different type of Low-Grade B-Cell lymphomas [i.e. marginal zone lymphomas with lymphoplasmacytic differentiation (n=3), splenic marginal area lymphoma with secondary lymph node invasion (n=1), unclassified marginal area lymphomas (n=8)]. Treatment of the underling lymphoma resulted in an improvement (n=8) or stabilization (n=4) of neurological disease.

CONCLUSION:

Atypical presentation of immune-related neurological syndromes, as well as the presence of antibodies with different antigenic targets should be regarded as "warning signs" and raise the suspicion of a paraneoplastic origin sustained by an underlying low-grade B-cell lymphoma that should be actively sought and treated. Close collaboration between internists, neurologists and hematologists allows for the appropriate management of each case.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Año: 2024 Tipo del documento: Article Pais de publicación: Alemania