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A novel tool for characterising upper limb function in progressive multiple sclerosis through kinematic assessment.
Fernandes, Linford; Coats, Rachel O; Mon-Williams, Mark; Hafeez, Awais; Holt, Raymond; Ford, Helen L.
Afiliación
  • Fernandes L; Leeds Teaching Hospitals NHS Trust, Centre for Neurosciences, UK. Electronic address: linford.fernandes@nhs.net.
  • Coats RO; University of Leeds, School of Psychology, UK.
  • Mon-Williams M; University of Leeds, School of Psychology, UK.
  • Hafeez A; University of Leeds, School of Mechanical Engineering, UK.
  • Holt R; University of Leeds, School of Mechanical Engineering, UK.
  • Ford HL; Leeds Teaching Hospitals NHS Trust, Centre for Neurosciences, UK.
J Neurol Sci ; 462: 123068, 2024 Jul 15.
Article en En | MEDLINE | ID: mdl-38850768
ABSTRACT

INTRODUCTION:

Current upper limb assessment methods in MS rely on measuring duration in tasks like the nine-hole peg test (9HPT). Kinematic techniques may provide a more useful measure of functional change in clinical and research practice. The aim of this study was to assess upper limb function prospectively in people with progressive MS using a kinematic 3D motion capture system and compare with current measures.

METHODS:

42 people with progressive MS (PwPMS) and 15 healthy controls reached-and-grasped different objects whilst recorded by a kinematic assessment system. 9HPT, Expanded Disability Status Scale (EDSS), and patient reported outcome measures (PROs) were collected. All measures were taken at baseline for PwPMS and controls, and again at six months for PwPMS.

RESULTS:

Relative to controls, PwPMS had significantly longer reaction (0.11 s, p < 0.05) and reach (0.25 s, p < 0.05) times. PwPMS took longer to pick-up (0.34 s, p < 0.05), move (0.14 s, p < 0.05), and place (0.18 s, p < 0.05) objects. PwPMS had lower peak velocities when reaching (7.4 cm/s, p < 0.05) and moving (7.3 cm/s, p < 0.05) objects. Kinematic assessment demonstrated consistent differences between PwPMS with mild and severe upper limb dysfunction as defined by PROs, which were not captured by 9HPT or EDSS in this group. PwPMS demonstrated altered grip apertures profiles, as measured by their ability to complete individual parts of the reach and grasp task, between the baseline and follow-up timepoints.

CONCLUSIONS:

We have created and tested a novel upper limb function assessment tool which has detected changes and characteristics in hand function, not currently captured by the EDSS and 9HPT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extremidad Superior / Evaluación de la Discapacidad Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extremidad Superior / Evaluación de la Discapacidad Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos