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Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.
Holl, Daniel; Hau, Wing Fung; Julien, Anais; Banitalebi, Shervin; Kalkitsas, Jannis; Savant, Soniya; Llorens-Bobadilla, Enric; Herault, Yann; Pavlovic, Guillaume; Amiry-Moghaddam, Mahmood; Dias, David Oliveira; Göritz, Christian.
Afiliación
  • Holl D; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Hau WF; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Julien A; Center for Neuromusculoskeletal Restorative Medicine, Shatin, Hong Kong.
  • Banitalebi S; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Kalkitsas J; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Savant S; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Llorens-Bobadilla E; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Herault Y; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Pavlovic G; Center for Neuromusculoskeletal Restorative Medicine, Shatin, Hong Kong.
  • Amiry-Moghaddam M; Université de Strasbourg, CNRS, INSERM, Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
  • Dias DO; Université de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN-Institut Clinique de la Souris, Illkirch-Graffenstaden, France.
  • Göritz C; Université de Strasbourg, CNRS, INSERM, Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Nat Neurosci ; 27(7): 1285-1298, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38849523
ABSTRACT
Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue regeneration and functional recovery. However, the origin of scar-forming fibroblasts is unclear. Here, we show that stromal fibroblasts forming the fibrotic scar derive from two populations of perivascular cells after spinal cord injury (SCI) in adult mice of both sexes. We anatomically and transcriptionally identify the two cell populations as pericytes and perivascular fibroblasts. Fibroblasts and pericytes are enriched in the white and gray matter regions of the spinal cord, respectively. Both cell populations are recruited in response to SCI and inflammation. However, their contribution to fibrotic scar tissue depends on the location of the lesion. Upon injury, pericytes and perivascular fibroblasts become activated and transcriptionally converge on the generation of stromal myofibroblasts. Our results show that pericytes and perivascular fibroblasts contribute to the fibrotic scar in a region-dependent manner.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Fibrosis / Cicatriz / Pericitos / Fibroblastos Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Fibrosis / Cicatriz / Pericitos / Fibroblastos Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos