Ultrafast light-activated polymeric nanomotors.

Wang, Jianhong; Wu, Hanglong; Zhu, Xiaowei; Zwolsman, Robby; Hofstraat, Stijn R J; Li, Yudong; Luo, Yingtong; Joosten, Rick R M; Friedrich, Heiner; Cao, Shoupeng; Abdelmohsen, Loai K E A; Shao, Jingxin; van Hest, Jan C M

Wang, Jianhong; Wu, Hanglong; Zhu, Xiaowei; Zwolsman, Robby; Hofstraat, Stijn R J; Li, Yudong; Luo, Yingtong; Joosten, Rick R M; Friedrich, Heiner; Cao, Shoupeng; Abdelmohsen, Loai K E A; Shao, Jingxin; van Hest, Jan C M.

Afiliación

Wang J; Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Wu H; Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Zhu X; School of Aeronautic Science and Engineering, Beihang University, Beijing, 100191, China.
Zwolsman R; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Hofstraat SRJ; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Li Y; Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Luo Y; Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Joosten RRM; Laboratory of Physical Chemistry, Department of Chemical Engineering & Chemistry, Center for Multiscale Electron Microscopy and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Friedrich H; Laboratory of Physical Chemistry, Department of Chemical Engineering & Chemistry, Center for Multiscale Electron Microscopy and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Cao S; College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, PR China.
Abdelmohsen LKEA; Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.
Shao J; Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands. J.Shao@tue.nl.
van Hest JCM; Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands. J.C.M.v.Hest@tue.nl.

Nat Commun ; 15(1): 4878, 2024 Jun 07.

Article en En | MEDLINE | ID: mdl-38849362

ABSTRACT

ABSTRACT

Synthetic micro/nanomotors have been extensively exploited over the past decade to achieve active transportation. This interest is a result of their broad range of potential applications, from environmental remediation to nanomedicine. Nevertheless, it still remains a challenge to build a fast-moving biodegradable polymeric nanomotor. Here we present a light-propelled nanomotor by introducing gold nanoparticles (Au NP) onto biodegradable bowl-shaped polymersomes (stomatocytes) via electrostatic and hydrogen bond interactions. These biodegradable nanomotors show controllable motion and remarkable velocities of up to 125 µm s-1. This unique behavior is explained via a thorough three-dimensional characterization of the nanomotor, particularly the size and the spatial distribution of Au NP, with cryogenic transmission electron microscopy (cryo-TEM) and cryo-electron tomography (cryo-ET). Our in-depth quantitative 3D analysis reveals that the motile features of these nanomotors are caused by the nonuniform distribution of Au NPs on the outer surface of the stomatocyte along the z-axial direction. Their excellent motile features are exploited for active cargo delivery into living cells. This study provides a new approach to develop robust, biodegradable soft nanomotors with application potential in biomedicine.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido

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