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Molecular and spatial evaluation of small rodents and Didelphimorphis infected with Mycobacterium leprae in the southern Amazon, Brazil.
de Souza Valois, Elderson Mariano; de Oliveira, Nathan Guilherme; de Lázari, Patrick Ricardo; da Silva, David José Ferreira; Rotelli, Raissa Campos; Batista, Lavínia Cássia Ferreira; Sobral, Marcos Henrique; Bortolomai, Bruna Eduarda; Finardi, Amanda Juliane; Levi, Taal; Peres, Carlos Augusto; de Morais Bronzoni, Roberta Vieira; Baptista, Ida Maria Foschiani Dias.
Afiliación
  • de Souza Valois EM; Medical School, São Paulo State University, Botucatu, Brazil.
  • de Oliveira NG; Medical School, São Paulo State University, Botucatu, Brazil.
  • de Lázari PR; Department of Biological Sciences, Laboratory of Mammalogy, State University of Mato Grosso, Caceres, Brazil.
  • da Silva DJF; Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop, Brazil.
  • Rotelli RC; Medical School, São Paulo State University, Botucatu, Brazil.
  • Batista LCF; Medical School, São Paulo State University, Botucatu, Brazil.
  • Sobral MH; Lauro de Souza Lima Institute, Bauru, Brazil.
  • Bortolomai BE; Medical School, São Paulo State University, Botucatu, Brazil.
  • Finardi AJ; Medical School, São Paulo State University, Botucatu, Brazil.
  • Levi T; College of Agricultural Sciences, Oregon State University, Corvallis, Oregon, USA.
  • Peres CA; School of Environmental Sciences, University of East Anglia, Norwich, UK.
  • de Morais Bronzoni RV; Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop, Brazil.
  • Baptista IMFD; Medical School, São Paulo State University, Botucatu, Brazil.
Zoonoses Public Health ; 71(6): 736-743, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38849303
ABSTRACT

BACKGROUND:

The high levels of recent transmission of leprosy worldwide demonstrate the necessity of epidemiologic surveillance to understand and control its dissemination. Brazil remains the second in number of cases around the world, indicating active transmission of Mycobacterium leprae (M. leprae) in the population. At this moment, there is a consensus that the bacillus is transmitted by inter-human contact, however, different serologic, molecular, and histopathological approaches indicate the existence of non-human transmission sources. METHODS AND

RESULTS:

The qPCR assay was used to amplify the molecular targets 16S RNAr and RLEP, in samples of liver, spleen, and ear of wild animals belonging to Didelphimorphia and Rodentia orders, in highly endemic areas of Mato Grosso, Brazil. The RLEP repetitive sequence was positive in 202 (89.0%) samples, with 96 (42.3%) of these also being positive for the 16S gene. Regarding the collection sites, it was observed that the animals were found in areas profoundly deforested, close to urban areas.

CONCLUSIONS:

Our results suggest that wild animals can play an important role in the maintenance of M. leprae in endemic regions with major anthropic action in Brazil. Therefore, integrating human, animal, and environmental health care with the One Health initiative is highly efficient for the development of effective strategies to contain and control leprosy in Brazil.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Roedores / Lepra / Mycobacterium leprae Límite: Animals / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Zoonoses Public Health Asunto de la revista: MEDICINA VETERINARIA / SAUDE PUBLICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Roedores / Lepra / Mycobacterium leprae Límite: Animals / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Zoonoses Public Health Asunto de la revista: MEDICINA VETERINARIA / SAUDE PUBLICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania