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Glutathione-responsive CD-MOFs co-loading honokiol and indocyanine green biomimetic active targeting to enhance photochemotherapy for breast cancer.
He, Yuanzhi; Guo, Jingwen; Ding, Huining; Lin, Min; Wu, Yihan; He, Zehui; Wang, Zhi; Xia, Qing; Zhu, Chunyun; Zhang, Yongtai; Feng, Nianping.
Afiliación
  • He Y; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Guo J; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Ding H; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Lin M; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Wu Y; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • He Z; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Wang Z; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Xia Q; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Zhu C; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Zhang Y; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: analysisdrug@126.com.
  • Feng N; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: npfeng@shutcm.edu.cn.
Int J Pharm ; 660: 124310, 2024 Jul 20.
Article en En | MEDLINE | ID: mdl-38848796
ABSTRACT
Breast cancer has now replaced lung cancer as the most prevalent malignant tumor worldwide, posing a serious health risk to women. We have recently designed a promising option strategy for the treatment of breast cancer. In this work, cyclodextrin metal-organic frameworks with high drug-carrying properties were endo-crosslinked by 3,3'dithiodipropionyl chloride to form cubic phase gel nanoparticles, which were drug-loaded and then coated by MCF-7 cell membranes. After intravenous injection, this multifunctional nanomedicine achieved dramatically homologous targeting co-delivery of honokiol and indocyanine green to the breast tumor. Further, the disulfide bonds in the nanostructures achieved glutathione-responsive drug release, induced tumor cells to produce reactive oxygen species and promoted apoptosis, resulting in tumor necrosis, and at the same time, inhibited Ki67 protein expression, which enhanced photochemotherapy, and resulted in a 94.08 % in vivo tumor suppression rate in transplanted tumor-bearing mice. Thereby, this nanomimetic co-delivery system may have a place in breast cancer therapy due to its simple fabrication process, excellent biocompatibility, efficient targeted delivery of insoluble drugs, and enhanced photochemotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Compuestos de Bifenilo / Neoplasias de la Mama / Lignanos / Liberación de Fármacos / Estructuras Metalorgánicas / Glutatión / Verde de Indocianina Límite: Animals / Female / Humans Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Compuestos de Bifenilo / Neoplasias de la Mama / Lignanos / Liberación de Fármacos / Estructuras Metalorgánicas / Glutatión / Verde de Indocianina Límite: Animals / Female / Humans Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos