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Mechanism-based and data-driven modeling in cell-free synthetic biology.
Yurchenko, Angelina; Özkul, Gökçe; van Riel, Natal A W; van Hest, Jan C M; de Greef, Tom F A.
Afiliación
  • Yurchenko A; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands. t.f.a.d.greef@tue.nl.
  • Özkul G; Institute for Complex Molecular Systems Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
  • van Riel NAW; Synthetic Biology Group, Department of Biomedical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
  • van Hest JCM; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands. t.f.a.d.greef@tue.nl.
  • de Greef TFA; Institute for Complex Molecular Systems Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Chem Commun (Camb) ; 60(51): 6466-6475, 2024 Jun 20.
Article en En | MEDLINE | ID: mdl-38847387
ABSTRACT
Cell-free systems have emerged as a versatile platform in synthetic biology, finding applications in various areas such as prototyping synthetic circuits, biosensor development, and biomanufacturing. To streamline the prototyping process, cell-free systems often incorporate a modeling step that predicts the outcomes of various experimental scenarios, providing a deeper insight into the underlying mechanisms and functions. There are two recognized approaches for modeling these systems mechanism-based modeling, which models the underlying reaction mechanisms; and data-driven modeling, which makes predictions based on data without preconceived interactions between system components. In this highlight, we focus on the latest advancements in both modeling approaches for cell-free systems, exploring their potential for the design and optimization of synthetic genetic circuits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Libre de Células / Biología Sintética Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Libre de Células / Biología Sintética Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido