Your browser doesn't support javascript.
loading
Changes in Rat Mammary Tissue Architecture Following Pregnancy/Lactation Exposure to Glyphosate Alone or with 2,4-D and Dicamba.
Cirstea, Andrei Eugen; Docea, Anca Oana; Cercelaru, Liliana; Drocas, Andrei Ioan; Mesnage, Robin; Marginean, Cristina; Marinas, Cristian; Diaconu, Magdalena; Golokhvast, Kirill S; Mitrut, Radu; Antoniou, Michael N; Tsatsakis, Aristidis; Calina, Daniela.
Afiliación
  • Cirstea AE; Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.
  • Docea AO; Department of Toxicology, University of Medicine and Pharmacy of Craiova, Romania.
  • Cercelaru L; Department of Anatomy and Embryology, University of Medicine and Pharmacy of Craiova, Romania.
  • Drocas AI; Department of Urology, University of Medicine and Pharmacy of Craiova, Romania.
  • Mesnage R; King's College London, Gene Expression and Therapy Group, Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, Guy's Hospital, London, SE1 9RT, UK.
  • Marginean C; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany.
  • Marinas C; Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania.
  • Diaconu M; Department of Obstetrics and Gynecology, Emergency Clinical County Hospital, Romania.
  • Golokhvast KS; Department of Human Anatomy, University of Medicine and Pharmacy of Craiova, Romania.
  • Mitrut R; Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.
  • Antoniou MN; Siberian Federal Scientific Center for Agrobiotechnology RAS, Krasnoobsk, Russia.
  • Tsatsakis A; Department of Cardiology, University and Emergency Hospital, 050098 Bucharest, Romania.
  • Calina D; King's College London, Gene Expression and Therapy Group, Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, Guy's Hospital, London, SE1 9RT, UK.
Curr Health Sci J ; 50(1): 94-105, 2024.
Article en En | MEDLINE | ID: mdl-38846475
ABSTRACT
The current study aimed to assess the possible endocrine disruptor effects on rat mammary tissue and reproductive organs during pregnancy and lactation when exposed to low doses of glyphosate and its combination with 2,4-dichlorophenoxyacetic acid (2,4-D) and dicamba. The study involved the exposure of pregnant Wistar rats to various regulatory-relevant doses of glyphosate, ranging from gestational day 6 until fine of the lactation period. Glyphosate doses corresponded to the European Union's glyphosate-acceptable daily intake (ADI; 0.5mg/kg bw/day) and no observed adverse effect level (NOAEL; 50mg/kg bw/day). The dose of the mixture of glyphosate, dicamba, and 2,4-D was at the European Union ADI for each herbicide namely 0.5, 0.002, and 0.3mg/kg bw/day, respectively. In the animals exposed to glyphosate NOAEL serum estradiol levels were increased compared to untreated animals, along with an upregulation of TNF-?, MMP-2, and MMP-9 as measured in mammary gland homogenates compared to non-treated animals. Moreover, in this group, a focally acute inflammatory infiltrate was observed in the mammary gland. Our study showed that short-term exposure to glyphosate at doses that are set as safe by regulators and thus without risk corroborated with a particular physiological state as gestation and lactation, can give rise to inflammatory changes in breast tissue in rats. These findings support the need for further evaluation of glyphosate and mixtures of glyphosate with other pesticides for public health protection, especially for those categories vulnerable to the potential endocrine disruptor properties of these pesticides such as pregnant women, newborns, and children.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Health Sci J Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Rumanía
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Health Sci J Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Rumanía