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Single-cell landscape reveals the immune heterogeneity of bone marrow involvement in peripheral T-cell lymphoma.
Liu, Jun; Xia, Baijing; Jiang, Xinmiao; Cao, Lixue; Xi, Zhihui; Liang, Liting; Zhang, Shaojun; Zhang, Hui; Li, Wenyu.
Afiliación
  • Liu J; Medical Research institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Xia B; Department of Precision Medicine, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
  • Jiang X; Medical Research institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Cao L; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
  • Xi Z; Department of Lymphoma, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Liang L; Medical Research institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Zhang S; Medical Research institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Zhang H; Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Li W; Medical Research institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Cancer Sci ; 115(8): 2540-2552, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38845192
ABSTRACT
The prognosis of patients with peripheral T-cell lymphoma (PTCL) depends on bone marrow involvement (BMI). The bone marrow (BM) tumor microenvironment in PTCL remains unclear. We performed single-cell RNA sequencing (scRNA-seq) on 11 fresh BM samples from patients with BMI to reveal the associations of immune landscape and genetic variations with the prognosis of PTCL patients. Compared with PTCL not otherwise specified (NOS), angioimmunoblastic T-cell lymphoma (AITL) had a higher number of T cells, lower number of lymphocytes, and greater inflammation. Immune heterogeneity in AITL is associated with prognosis. In particular, specific T-cell receptor (TCR) T cells are enriched in patients with good response to anti-CD30 therapy. We observed RhoA mutation-associated neoantigens. Chidamide-treated patients had a higher number of CD4+ regulatory cells and a better treatment response compared with other patients. In the nonresponder group, T-cell enrichment progressed to secondary B-cell enrichment and subsequently diffuse large B-cell lymphoma. Moreover, AITL patients with lymphoma-associated hemophagocytic syndrome had more T follicular helper (Tfh) cells with copy number variations in CHR5. To our knowledge, this study is the first to reveal the single-cell landscape of BM microenvironment heterogeneity in PTCL patients with BMI. scRNA-seq can be used to investigate the immune heterogeneity and genetic variations in AITL associated with prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Linfoma de Células T Periférico / Análisis de la Célula Individual / Microambiente Tumoral Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Linfoma de Células T Periférico / Análisis de la Célula Individual / Microambiente Tumoral Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido