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Two onset types of achalasia and the long-term course to diagnosis.
Kurosugi, Akane; Matsumura, Tomoaki; Sonoda, Michiko; Kaneko, Tatsuya; Takahashi, Satsuki; Okimoto, Kenichiro; Akizue, Naoki; Ohyama, Yuhei; Mamiya, Yukiyo; Nakazawa, Hayato; Horio, Ryosuke; Goto, Chihiro; Ohta, Yuki; Taida, Takashi; Kikuchi, Atsuko; Fujie, Mai; Murakami, Kentaro; Uesato, Masaya; Ozawa, Yoshihito; Kato, Jun; Matsubara, Hisahiro; Kato, Naoya.
Afiliación
  • Kurosugi A; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Matsumura T; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan. matsumura@chiba-u.jp.
  • Sonoda M; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Kaneko T; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Takahashi S; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Okimoto K; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Akizue N; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Ohyama Y; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Mamiya Y; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Nakazawa H; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Horio R; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Goto C; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Ohta Y; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Taida T; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Kikuchi A; Clinical Research Center, Chiba University, Chiba, Japan.
  • Fujie M; Clinical Research Center, Chiba University, Chiba, Japan.
  • Murakami K; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Uesato M; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Ozawa Y; Department of Clinical Engineering Center, Chiba University Hospital, Chiba, Japan.
  • Kato J; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
  • Matsubara H; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Kato N; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan.
Esophagus ; 21(4): 546-551, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38844704
ABSTRACT

BACKGROUND:

Recently, the incidence of achalasia has been increasing, but its cause remains unknown. This study aimed to examine the initial symptoms and the course of symptoms and to find new insights into the cause and course of the disease.

METHODS:

Altogether, 136 patients diagnosed with achalasia by high-resolution manometry (HRM) were enrolled. Questionnaires and chart reviews were conducted to investigate the initial symptoms, time from onset to diagnosis, and comorbidities, as well as the relationship between HRM results, time to diagnosis, and symptom severity.

RESULTS:

In total, 67 of 136 patients responded to the questionnaire. The median ages of onset and diagnosis were 42 and 58 years, respectively. The median time from onset to diagnosis was 78.6 months, with 25 cases (37.3%) taking > 10 years to be diagnosed. The symptom onset was gradual and sudden in 52 (77.6%) and 11 (16.4%) patients, respectively. Of the 11 patients with acute onset, three (27.3%) developed anhidrosis at the same time. There was no correlation between the time from onset to diagnosis and esophageal dilatation, resting LES pressure, or mean integrated relaxation pressure (IRP). No correlation was also found between the degree of symptoms and resting LES pressure or IRP.

CONCLUSION:

Esophageal achalasia can have acute or insidious onsets. This finding may help to elucidate the cause of achalasia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acalasia del Esófago / Manometría Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Esophagus Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acalasia del Esófago / Manometría Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Esophagus Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón