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Is premorbid stress assessed by hair cortisol concentration linked to Takotsubo syndrome? Results from a pilot study.
Rallidis, Loukianos S; Papathanasiou, Konstantinos A; Kosmas, Nikolaos; Iordanidis, Dimitrios; Rallidis, Stylianos L; Simitsis, Panagiotis.
Afiliación
  • Rallidis LS; 2nd Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital ATTIKON, Athens, Greece. Electronic address: lrallidis@gmail.com.
  • Papathanasiou KA; 2nd Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital ATTIKON, Athens, Greece.
  • Kosmas N; 2nd Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital ATTIKON, Athens, Greece.
  • Iordanidis D; 2nd Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital ATTIKON, Athens, Greece.
  • Rallidis SL; BSc of Biomedical Sciences, University of Nicosia Medical School, Cyprus.
  • Simitsis P; 2nd Department of Cardiology, Medical School, National and Kapodistrian University of Athens, University General Hospital ATTIKON, Athens, Greece.
Int J Cardiol ; 410: 132241, 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-38844095
ABSTRACT

INTRODUCTION:

The pathophysiology of Takotsubo syndrome (TTS) is not completely understood and the role of chronic stress is among the main mechanistic links. The aim of this study was to explore whether accumulating hair cortisol concentration (HCC), a novel biomarker of chronic stress, is associated with the occurrence of TTS.

METHODS:

A consecutive series of 18 TTS patients and 36 age and sex matched healthy controls were included in our analysis. Hair samples were collected from participants'' vertex. The proximal 2.5 cm of hair was cut in equal parts of 0.5 cm, reflecting mean cortisol levels in time intervals of 0-15, 15-30, 30-45, 45-60 and 60-75 days prior to hair collection.

RESULTS:

HCC was higher in TTS group compared to controls at any time point and increased over time starting from 75 days prior to the event. The rate of HCC increase was significantly higher in TTS patients versus controls (beta of interaction = 0.48; 95%CI 0.36-0.60; p < 0.001).

CONCLUSIONS:

The steadily increasing trend of HCC in TTS patients suggests that the additive effect of multiple stressful events over several weeks prior TTS onset may disrupt cortisol homeostasis and play a role in TTS pathophysiology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Hidrocortisona / Biomarcadores / Cardiomiopatía de Takotsubo / Cabello Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Hidrocortisona / Biomarcadores / Cardiomiopatía de Takotsubo / Cabello Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos