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The efficacy and assessment value of the level of thyroglobulin wash-out after fine-needle aspiration cytodiagnosis in the evaluation of lymph node metastasis in papillary thyroid carcinoma.
Chen, Jie; Lin, Zongwu; Xu, Bo; Lu, Tianwen; Zhang, Xinghai.
Afiliación
  • Chen J; Thyroid and Breast Surgery, Department of General Surgery, Wanbei Coal and Power Group General Hospital affiliated With Bengbu Medical University, Su Zhou, Anhui Province, China.
  • Lin Z; Thyroid and Breast Surgery, Department of General Surgery, Wanbei Coal and Power Group General Hospital affiliated With Bengbu Medical University, Su Zhou, Anhui Province, China.
  • Xu B; Thyroid and Breast Surgery, Department of General Surgery, Wanbei Coal and Power Group General Hospital affiliated With Bengbu Medical University, Su Zhou, Anhui Province, China.
  • Lu T; Thyroid and Breast Surgery, Department of General Surgery, Wanbei Coal and Power Group General Hospital affiliated With Bengbu Medical University, Su Zhou, Anhui Province, China.
  • Zhang X; Thyroid and Breast Surgery, Department of General Surgery, Wanbei Coal and Power Group General Hospital affiliated With Bengbu Medical University, Su Zhou, Anhui Province, China. zxh1258@126.com.
World J Surg Oncol ; 22(1): 149, 2024 Jun 05.
Article en En | MEDLINE | ID: mdl-38840197
ABSTRACT

OBJECTIVE:

The purpose of this study was to evaluate the efficacy and clinical value of US, FNAC,FNA-Tg and FNAC + FNA-Tg, as well as the cutoff values of FNA-Tg to evaluate LN metastasis.

METHODS:

We analyzed the diagnostic value of different US signs, the efficiency of US, FNAC, FNA-Tg and FNAC + FNA-Tg among the LN- and LN + groups, and the cutoff value of FNA-Tg to evaluate LN metastasis. We punctured LNs multiple times and measured the levels of FNA-Tg. Furthermore, the LNs were marked with immunohistochemical Tg and LCA to distinguish the presence of Tg in the para-cancerous tissue of the LNs.

RESULTS:

The s-Tg and FNA-Tg of the LN + group were higher than those of the LN- group (P = 0.018, ≤ 0.001). The LN + group had more abnormal US signs than the LN- group. The cutoff value of FNA-Tg was 3.2 ng/mL. US had a high sensitivity (92.42), but the specificity was not satisfactory (55.1). FNA-Tg had a higher sensitivity (92.42 vs. 89.39), specificity (100 vs. 93.88), and accuracy (92.42 vs. 83.27) than FNAC. However, the sensitivity of FNAC + FNA-Tg increased further, while the specificity and accuracy decreased slightly. The presence of Tg in the normal lymphocytes adjacent to the cancer was confirmed.

CONCLUSION:

Ultrasonography provides a noninvasive, dynamic, multidimensional assessment of LNs. With a cutoff value of 3.2 ng/mL, FNA-Tg has higher accuracy and a lower false-negative rate than various single diagnoses. However, FNAC combined with FNA-Tg does not cause additional pain to patients and offers a higher diagnostic efficacy and clinical value.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroglobulina / Neoplasias de la Tiroides / Metástasis Linfática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Surg Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroglobulina / Neoplasias de la Tiroides / Metástasis Linfática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Surg Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido