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Visceral fat area is more strongly associated with arterial stiffness than abdominal subcutaneous fat area in Chinese patients with type 2 diabetes.
Mao, Jing; Gan, Shenglian; Gong, Shijun; Zhou, Quan; Yu, Fang; Zhou, Haifeng; Lu, Huilin; Li, Qian; Deng, Zhiming.
Afiliación
  • Mao J; Department of Science and Education, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
  • Gan S; Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
  • Gong S; Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
  • Zhou Q; Department of Ultrasound, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
  • Yu F; Department of Science and Education, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
  • Zhou H; Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
  • Lu H; Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
  • Li Q; Department of Endocrinology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
  • Deng Z; Department of Pulmonary and Critical Care Medicine, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.
Diabetol Metab Syndr ; 16(1): 123, 2024 Jun 05.
Article en En | MEDLINE | ID: mdl-38840161
ABSTRACT

BACKGROUND:

Few studies have compared the correlation between visceral fat area (VFA) and abdominal subcutaneous fat area (SFA) with arterial stiffness (AS) in patients with type 2 diabetes (T2D). In addition, there is currently controversy regarding the correlation between VFA and SFA with AS. We aimed to investigate the relationship between VFA and SFA with AS in patients with T2D.

METHODS:

In this cross-sectional study, 1475 Chinese T2D patients with an average age of 52.32 ± 10.96 years were included. VFA and SFA were determined by a dual bioelectrical impedance analyzer, and AS was determined by measurement of brachial-ankle pulse wave conduction velocity (baPWV). Atherosclerosis was deemed present in study participants with baPWV values higher than 75th percentile (1781 cm/s). Independent correlations of logVFA and logSFA with AS were assessed using multiple linear regression and multivariate logistic regression.

RESULTS:

The baPWV was linked with VFA, waist circumference, and women's SFA in a general linear correlation study (P < 0.05), but not with body mass index (P = 0.3783) or men's SFA (P = 0.1899). In both men and women, VFA and SFA were positively correlated with AS, according to the generalized additive model (GAM). After fully adjusting for confounders, multiple linear regression analyses showed that for every 1-unit increase in logVFA, the beta coefficient of baPWV increased by 63.1 cm/s (95% CI 18.4, 107.8) (P < 0.05). logSFA did not correlate significantly with baPWV (P = 0.125). In the multiple logistic regression analysis, the odds ratio (OR) of elevated baPWV was 1.8 (95% CI 1.1, 3.1) (P = 0.019) per 1-unit increase in logVFA. logSFA did not correlate significantly with AS (P = 0.091). In the subgroup analysis, the correlation between logVFA and baPWV did not interact across subgroups (P-interaction > 0.05).

CONCLUSIONS:

Compared with SFA, VFA had a stronger independent positive correlation with AS in Chinese T2D patients. Patients with T2D should pay more attention to monitoring VFA and lowering it to minimize cardiovascular events.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetol Metab Syndr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetol Metab Syndr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido