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Prognostic importance of modified geriatric nutritional risk index in oral cavity squamous cell carcinoma.
Tsai, Yao-Te; Tsai, Ming-Hsien; Chang, Geng-He; Tsai, Ming-Shao; Huang, Ethan I; Lu, Chang-Hsien; Hsu, Cheng-Ming; Lai, Chia-Hsuan; Liao, Chun-Ta; Kang, Chung-Jan; Lee, Yi-Chan; Tsai, Yuan-Hsiung; Fang, Ku-Hao.
Afiliación
  • Tsai YT; Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
  • Tsai MH; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Chang GH; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Tsai MS; Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
  • Huang EI; Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
  • Lu CH; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Hsu CM; Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
  • Lai CH; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Liao CT; Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
  • Kang CJ; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Lee YC; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Tsai YH; Department of Hematology and Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
  • Fang KH; Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Sci Rep ; 14(1): 12921, 2024 06 05.
Article en En | MEDLINE | ID: mdl-38839809
ABSTRACT
We probed the associations of preoperative modified geriatric nutritional risk index (mGNRI) values with prognosis in patients receiving surgery for oral cavity squamous cell carcinoma (OCSCC). This retrospective study analyzed the clinical data of 333 patients with OCSCC and undergoing surgery between 2008 and 2017. The preoperative mGNRI was calculated using the following formula (14.89/C-reactive protein level) + 41.7 × (actual body weight/ideal body weight). We executed receiver operating characteristic curve analyses to derive the optimal mGNRI cutoff and employed Kaplan-Meier survival curves and Cox proportional hazard model to probe the associations of the mGNRI with overall survival (OS) and disease-free survival (DFS). The optimal mGNRI cutoff was derived to be 73.3. We noted the 5-year OS and DFS rates to be significantly higher in the high-mGNRI group than in the low-mGNRI group (both p < 0.001). A preoperative mGNRI below 73.3 was independently associated with unfavorable DFS and OS. A mGNRI-based nomogram was constructed to provide accurate OS predictions (concordance index, 0.781). Hence, preoperative mGNRI is a valuable and cost-effective prognostic biomarker in patients with OCSCC. Our nomogram facilitates the practical use of mGNRI and offers individualized predictions of OS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Evaluación Nutricional Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Evaluación Nutricional Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido