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The effects of electrical stimulation of ventromedial prefrontal cortex on skin sympathetic nerve activity.
Patel, Mariya; Braun, Joe A; Henderson, Luke A; Dawood, Tye; Macefield, Vaughan G.
Afiliación
  • Patel M; Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.
  • Braun JA; Baker Department of Cardiometabolic Health, The University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia.
  • Henderson LA; Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.
  • Dawood T; Department of Neuroscience, Monash University, The Alfred Centre, 99 Commercial Road, Melbourne, VIC 3004, Australia.
  • Macefield VG; School of Medical Sciences (Neuroscience), Brain and Mind Centre, The University of Sydney, 94 Mallett Street, Sydney, NSW 2006, Australia.
Cereb Cortex ; 34(6)2024 Jun 04.
Article en En | MEDLINE | ID: mdl-38839074
ABSTRACT
Skin sympathetic nerve activity (SSNA) is primarily involved in thermoregulation and emotional expression; however, the brain regions involved in the generation of SSNA are not completely understood. In recent years, our laboratory has shown that blood-oxygen-level-dependent signal intensity in the ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) are positively correlated with bursts of SSNA during emotional arousal and increases in signal intensity in the vmPFC occurring with increases in spontaneous bursts of SSNA even in the resting state. We have recently shown that unilateral transcranial alternating current stimulation (tACS) of the dlPFC causes modulation of SSNA but given that the current was delivered between electrodes over the dlPFC and the nasion, it is possible that the effects were due to current acting on the vmPFC. To test this, we delivered tACS to target the right vmPFC or dlPFC and nasion and recorded SSNA in 11 healthy participants by inserting a tungsten microelectrode into the right common peroneal nerve. The similarity in SSNA modulation between ipsilateral vmPFC and dlPFC suggests that the ipsilateral vmPFC, rather than the dlPFC, may be causing the modulation of SSNA during ipsilateral dlPFC stimulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Sistema Nervioso Simpático / Corteza Prefrontal / Estimulación Transcraneal de Corriente Directa Límite: Adult / Female / Humans / Male Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Sistema Nervioso Simpático / Corteza Prefrontal / Estimulación Transcraneal de Corriente Directa Límite: Adult / Female / Humans / Male Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos