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Comprehensive review on glucose 6 phosphate dehydrogenase: A critical immunometabolic and redox switch in insects.
Ghani, Muhammad Usman; Yang, Zihan; Feng, Tianxiang; Chen, Junfan; Khosravi, Zahra; Wu, Qishu; Cui, Hongjuan.
Afiliación
  • Ghani MU; State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China; Medical Research Institute, Southwest University, Chongqing 400715, China.
  • Yang Z; Medical Research Institute, Southwest University, Chongqing 400715, China.
  • Feng T; Medical Research Institute, Southwest University, Chongqing 400715, China.
  • Chen J; State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China.
  • Khosravi Z; State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China.
  • Wu Q; State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China.
  • Cui H; State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China; Medical Research Institute, Southwest University, Chongqing 400715, China; Jinfeng Laboratory, Chongqing, 401329, China. Electronic address: hcui@swu.edu.cn.
Int J Biol Macromol ; 273(Pt 2): 132867, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38838892
ABSTRACT
Mounting an active immune response is energy intensive and demands the reallocation of nutrients to maintain the body's resistance and tolerance against infections. Central to this metabolic adaptation is Glucose-6-phosphate dehydrogenase (G6PDH), a housekeeping enzyme involve in pentose phosphate pathway (PPP). PPP play an essential role in generating ribose, which is critical for nicotinamide adenine dinucleotide phosphate (NADPH). It is vital for physiological and cellular processes such as generating nucleotides, fatty acids and reducing oxidative stress. The G6PDH is extremely conserved enzyme across species in PP shunt. The deficiency of enzymes leads to serious consequences on organism, particularly on adaptation and development. Acute deficiency can lead to impaired cell development, halted embryonic growth, reduce sensitivity to insulin, hypertension and increase inflammation. Historically, research focusing on G6PDH and PPP have primarily targeted diseases on mammalian. However, our review has investigated the unique functions of the G6PDH enzyme in insects and greatly improved mechanistic understanding of its operations. This review explore how G6PDH in insects plays a crucial role in managing the redox balance and immune related metabolism. This study aims to investigate the enzyme's role in different metabolic adaptations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Glucosafosfato Deshidrogenasa / Insectos Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Glucosafosfato Deshidrogenasa / Insectos Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos