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Causal role of immune cells in major depressive disorder and bipolar disorder: Mendelian randomization (MR) study.
Zhang, Yi; Wang, San-Wang; Ding, Jiahao; Wen, Xin; Li, Tingting; Yang, Lu; Peng, Jintao; Dong, Yingying; Mi, Weifeng; Gao, Yujun; Sun, Guizhi.
Afiliación
  • Zhang Y; Department of Psychiatry, Binzhou Medical University Hospital, Binzhou, China; Department of Psychiatry, Wuhan Wuchang Hospital, Wuhan University of Science and Technology, Wuhan, 430063, China.
  • Wang SW; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth
  • Ding J; Shandong First Medical University (Shandong Academy Of Medical Sciences) No. 6699, Qingdao Road, Huaiyin District, Jinan City, Shandong Province, China.
  • Wen X; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-
  • Li T; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-
  • Yang L; Department of Psychiatry, Binzhou Medical University Hospital, Binzhou, China; Department of Psychiatry, Wuhan Wuchang Hospital, Wuhan University of Science and Technology, Wuhan, 430063, China.
  • Peng J; Department of Psychiatry, Binzhou Medical University Hospital, Binzhou, China; Department of Psychiatry, Wuhan Wuchang Hospital, Wuhan University of Science and Technology, Wuhan, 430063, China.
  • Dong Y; Department of Psychiatry, Binzhou Medical University Hospital, Binzhou, China.
  • Mi W; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-
  • Gao Y; Clinical and Translational Sciences (CaTS) Lab, The Douglas Research Centre, McGill University, Montréal, Québec, Canada; Binzhou Medical University, Binzhou, China. Electronic address: Yujun_Gao@whu.edu.cn.
  • Sun G; Department of Psychiatry, Binzhou Medical University Hospital, Binzhou, China. Electronic address: sunguizhi@126.com.
J Affect Disord ; 361: 165-171, 2024 Sep 15.
Article en En | MEDLINE | ID: mdl-38838789
ABSTRACT

BACKGROUND:

Major depressive disorder (MDD) and bipolar disorder (BD) are prevalent psychiatric conditions linked to inflammatory processes. However, it is unclear whether associations of immune cells with these disorders are likely to be causal.

METHODS:

We used two-sample Mendelian randomization (MR) approach to investigate the relationship between 731 immune cells and the risk of MDD and BD. Rigorous sensitivity analyses are conducted to assess the reliability, heterogeneity, and horizontal pleiotropy of the findings.

RESULTS:

Genetically-predicted CD27 on IgD+ CD38- unswitched memory B cell (inverse variance weighting (IVW) odds ratio (OR) [95 %] 1.017 [1.007 to 1.027], p = 0.001), CD27 on IgD+ CD24+ B cell (IVW OR [95 %] 1.021 [1.011 to 1.031], p = 4.821E-05) and other 12 immune cells were associated with increased risk of MDD in MR, while HLA DR++ monocyte %leukocyte (IVW OR [95 %] 0.973 [0.948 to 0.998], p = 0.038), CD4 on Central Memory CD4+ T cell (IVW OR [95 %] 0.979 [0.963 to 0.995], p = 0.011) and other 13 immune cells were associated with decreased risk of MDD in MR. Additionally, CD33+ HLA DR+ Absolute Count (IVW OR [95 %] 1.022[1.007 to 1.036], p = 0.007), CD28+ CD45RA- CD8+ T cell %T cell (IVW OR [95 %] 1.024 [1.008 to 1.041], p = 0.004) and other 18 immune cells were associated with increased risk of BD in MR, while CD62L on CD62L+ myeloid Dendritic Cell (IVW OR [95 %] 0.926 [0.871 to 0.985], p = 0.014), IgD- CD27- B cell %lymphocyte (IVW OR [95 %] 0.918 [0.880 to 0.956], p = 4.654E-05) and other 13 immune cells were associated with decreased risk of BD in MR.

CONCLUSIONS:

This MR study provides robust evidence supporting a causal relationship between immune cells and the susceptibility to MDD and BD, offering valuable insights for future clinical investigations. Experimental studies are also required to further examine causality, mechanisms, and treatment potential for these immune cells for MDD and BD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Trastorno Depresivo Mayor / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Trastorno Depresivo Mayor / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos