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Additive Manufacturing of Biodegradable Molybdenum - From Powder to Vascular Stent.
Bian, Dong; Tong, Zhipei; Gong, Gencheng; Huang, He; Fang, Liudang; Yang, Hongtao; Gu, Wenda; Yu, Hui; Zheng, Yufeng.
Afiliación
  • Bian D; Medical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
  • Tong Z; Medical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
  • Gong G; Medical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
  • Huang H; School of Medicine, South China University of Technology, Guangzhou, 510006, China.
  • Fang L; School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450003, China.
  • Yang H; School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450003, China.
  • Gu W; School of Engineering Medicine, Beihang University, Beijing, 100191, China.
  • Yu H; Department of Cardiac Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
  • Zheng Y; Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, Department of Orthopaedic Surgery, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical Univ
Adv Mater ; 36(32): e2401614, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38837830
ABSTRACT
Magnesium, iron, and zinc-based biodegradable metals are widely recognized as promising candidate materials for the next generation of bioresorbable stent (BVS). However, none of those metal BVSs are perfect at this stage. Here, a brand-new BVS based on a novel biodegradable metal (Molybdenum, Mo) through additive manufacturing is developed. Nearly full-dense and crack-free thin-wall Mo is directly manufactured through selective laser melting (SLM) with fine Mo powder. Systemic analyses considering the forming quality, wall-thickness, microstructure, mechanical properties, and in vitro degradation behaviors are performed. Then, Mo-based thin-strut (≤ 100 µm) stents are successfully obtained through an optimized single-track laser melting route. The SLMed thin-wall Mo owns comparable strength to its Mg and Zn based counterparts (as-drawn), while, it exhibits remarkable biocompatibility in vitro. Vessel related cells are well adhered and spread on SLMed Mo, and it exhibits a low risk of hemolysis and thrombus. The SLMed stent is compatible to vessel tissues in rat abdominal aorta, and it can provide sufficient support in an animal model as an extravascular stent. This work possibly opens a new era of manufacturing Mo-based stents through additive manufacturing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polvos / Stents / Implantes Absorbibles / Molibdeno Límite: Animals / Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polvos / Stents / Implantes Absorbibles / Molibdeno Límite: Animals / Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania