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Impact of Cutaneous Squamous Cell Carcinoma Histologic Features on Percent Interrater Agreement Regarding Tumor Differentiation.
Shahwan, Kathryn T; Varra, Vamsi; Nash, Jessica; Chung, Catherine G; Buckley, Kaila A; McIlwee, Bridget E; Carr, David R.
Afiliación
  • Shahwan KT; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio.
  • Varra V; Department of Internal Medicine, University of North Dakota Medical School, Grand Forks, North Dakota.
  • Nash J; Altru Health System, Grand Forks, North Dakota.
  • Chung CG; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio.
  • Buckley KA; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio.
  • McIlwee BE; Transitional Year Residency Program, Kettering Health, Kettering, Ohio.
  • Carr DR; Department of Dermatology, The Ohio State University Medical Center, Columbus, Ohio.
Dermatol Surg ; 2024 Jun 05.
Article en En | MEDLINE | ID: mdl-38837766
ABSTRACT

BACKGROUND:

Poor differentiation predicts adverse outcomes in cutaneous squamous cell carcinoma (CSCC), but there is no standardized, reliable grading system.

OBJECTIVE:

To explore which histologic features have the greatest impact on CSCC differentiation interrater agreement. MATERIALS AND

METHODS:

In a prior study, 40 raters graded differentiation for 45 squamous cell carcinomas, and percent interrater agreements were calculated. Cases graded as well/moderately differentiated with 100% agreement (10), those graded as poorly differentiated with ≥80% agreement (5), and those that received a variety of grades with ≤60% agreement (7) were pulled for the current study. Three raters graded individual histologic features for each case, and percent interrater agreements were calculated using both the well/moderately/poorly differentiated grading system and a dichotomized system.

RESULTS:

The percent interrater agreements were 34.8% for mitoses, 53% for pleomorphism, 59.1% for keratinization, 66.7% for cellular cohesion/intercellular bridges, and 78.8% for tumor edges. Percent agreements improved with dichotomous grading; the largest improvement was seen within the group of cases that had been graded as well/moderately differentiated with 100% agreement in the prior study.

CONCLUSION:

Future squamous cell carcinoma differentiation grading systems would benefit from eliminating mitotic rate, clearly defining how to grade other features, and dichotomous grading.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dermatol Surg Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dermatol Surg Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos