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Hepatic arterial infusion chemotherapy combined with toripalimab and surufatinib for the treatment of advanced intrahepatic cholangiocarcinoma.
Song, Songlin; Liu, Yiming; Ren, Yanqiao; Zheng, Chuansheng; Liang, Bin.
Afiliación
  • Song S; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu Y; Hubei Provinve Key Laboratory of Molecular Imaging, Wuhan, China.
  • Ren Y; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zheng C; Hubei Provinve Key Laboratory of Molecular Imaging, Wuhan, China.
  • Liang B; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Diagn Interv Radiol ; 2024 Jun 03.
Article en En | MEDLINE | ID: mdl-38836437
ABSTRACT

PURPOSE:

The aim of the present study is to report the clinical results of patients with advanced intrahepatic cholangiocarcinoma (ICC) who received combination therapy of hepatic arterial infusion chemotherapy (HAIC), toripalimab and surufatinib.

METHODS:

The study cohort consisted of 28 patients with advanced ICC who were treated with HAIC (mFOLFOX6 regimen, Q3W) in combination with intravenous toripalimab (240 mg, Q3W) and oral surufatinib (150 mg, once daily). The cohort had 14 male and 14 female patients. The baseline characteristics of the study cohort were obtained. The tumor response and drug-associated toxicity were assessed and reported.

RESULTS:

During the follow-up period (median follow-up time 11.3 months; range 4-19 months), four patients died of tumor progression. The objective response rate and disease control rate were 58% and 79%, respectively. The mPFS was 9.5 months, and the overall survival rate was 83.3%. The most frequent adverse events were nausea and vomiting (100%) and abdominal pain (85.7%). Serious complications related to death were not observed.

CONCLUSION:

The combination treatment schedule for advanced ICC demonstrated positive efficacy and safety profiles. CLINICAL

SIGNIFICANCE:

This study provides promising clinical guidance for the treatment of advanced cholangiocarcinoma and is expected to modify the treatment strategy for this disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagn Interv Radiol Asunto de la revista: DIAGNOSTICO POR IMAGEM / RADIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Turquía
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagn Interv Radiol Asunto de la revista: DIAGNOSTICO POR IMAGEM / RADIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Turquía