Your browser doesn't support javascript.
loading
Daytime plasma cortisol and cortisol response to dexamethasone suppression are associated with a prothrombotic state in hypertension.
Brosolo, Gabriele; Da Porto, Andrea; Bulfone, Luca; Vacca, Antonio; Bertin, Nicole; Vivarelli, Cinzia; Catena, Cristiana; Sechi, Leonardo A.
Afiliación
  • Brosolo G; Internal Medicine and European Hypertension Excellence Center, Department of Medicine, University of Udine, Udine, Italy.
  • Da Porto A; Diabetes and Metabolism Unit, Department of Medicine, University of Udine, Udine, Italy.
  • Bulfone L; Internal Medicine and European Hypertension Excellence Center, Department of Medicine, University of Udine, Udine, Italy.
  • Vacca A; Internal Medicine and European Hypertension Excellence Center, Department of Medicine, University of Udine, Udine, Italy.
  • Bertin N; Thrombosis and Hemostasis Unit, Department of Medicine, University of Udine, Udine, Italy.
  • Vivarelli C; Internal Medicine and European Hypertension Excellence Center, Department of Medicine, University of Udine, Udine, Italy.
  • Catena C; Internal Medicine and European Hypertension Excellence Center, Department of Medicine, University of Udine, Udine, Italy.
  • Sechi LA; Internal Medicine and European Hypertension Excellence Center, Department of Medicine, University of Udine, Udine, Italy.
Front Endocrinol (Lausanne) ; 15: 1397062, 2024.
Article en En | MEDLINE | ID: mdl-38836224
ABSTRACT
Background and

aims:

A prothrombotic state was demonstrated in patients with Cushing's syndrome and is involved in the development and progression of cardiovascular and renal damage in hypertensive patients. This study was designed to examine the relationships between cortisol secretion and the hemostatic and fibrinolytic systems in hypertension.

Methods:

In 149 middle-aged, nondiabetic, essential hypertensive patients free of cardiovascular and renal complications, we measured hemostatic markers that express the spontaneous activation of the coagulation and fibrinolytic systems and assessed daily cortisol levels (8 AM, 3 PM, 12 AM; area under the curve, AUC-cortisol) together with the cortisol response to dexamethasone overnight suppression (DST-cortisol).

Results:

Plasma levels of D-dimer (D-dim), prothrombin fragment 1 + 2 (F1 + 2), and von Willebrand factor (vWF) were progressively and significantly higher across tertiles of AUC-cortisol and DST-cortisol, whereas no differences were observed in fibrinogen, tissue plasminogen activator, plasminogen activator inhibitor-1, antithrombin III, protein C, and protein S. D-dim, F1 + 2, and vWF were significantly and directly correlated with age and both AUC-cortisol and DST-cortisol. Multivariate regression analysis showed that both AUC-cortisol and DST-cortisol were related to plasma D-dim, F1 + 2, and vWF independently of age, body mass index, blood pressure, and renal function.

Conclusion:

Greater daily cortisol profile and cortisol response to overnight suppression are independently associated with a prothrombotic state in hypertensive patients and might contribute to the development of organ damage and higher risk of cardiovascular complications.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dexametasona / Hidrocortisona / Hipertensión Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dexametasona / Hidrocortisona / Hipertensión Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza