Your browser doesn't support javascript.
loading
Molecular and Epidemiological Investigation of Fluconazole-resistant Candida parapsilosis-Georgia, United States, 2021.
Misas, Elizabeth; Witt, Lucy S; Farley, Monica M; Thomas, Stepy; Jenkins, Emily N; Gade, Lalitha; Peterson, Joyce G; Mesa Restrepo, Ana; Fridkin, Scott; Lockhart, Shawn R; Chow, Nancy A; Lyman, Meghan.
Afiliación
  • Misas E; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Witt LS; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Farley MM; Georgia Emerging Infections Program, Atlanta, Georgia, USA.
  • Thomas S; Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.
  • Jenkins EN; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Gade L; Georgia Emerging Infections Program, Atlanta, Georgia, USA.
  • Peterson JG; Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.
  • Mesa Restrepo A; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Fridkin S; Georgia Emerging Infections Program, Atlanta, Georgia, USA.
  • Lockhart SR; Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA.
  • Chow NA; Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Lyman M; ASRT, Inc., Atlanta, Georgia, USA.
Open Forum Infect Dis ; 11(6): ofae264, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38835496
ABSTRACT

Background:

Reports of fluconazole-resistant Candida parapsilosis bloodstream infections are increasing. We describe a cluster of fluconazole-resistant C parapsilosis bloodstream infections identified in 2021 on routine surveillance by the Georgia Emerging Infections Program in conjunction with the Centers for Disease Control and Prevention.

Methods:

Whole-genome sequencing was used to analyze C parapsilosis bloodstream infections isolates. Epidemiological data were obtained from medical records. A social network analysis was conducted using Georgia Hospital Discharge Data.

Results:

Twenty fluconazole-resistant isolates were identified in 2021, representing the largest proportion (34%) of fluconazole-resistant C parapsilosis bloodstream infections identified in Georgia since surveillance began in 2008. All resistant isolates were closely genetically related and contained the Y132F mutation in the ERG11 gene. Patients with fluconazole-resistant isolates were more likely to have resided at long-term acute care hospitals compared with patients with susceptible isolates (P = .01). There was a trend toward increased mechanical ventilation and prior azole use in patients with fluconazole-resistant isolates. Social network analysis revealed that patients with fluconazole-resistant isolates interfaced with a distinct set of healthcare facilities centered around 2 long-term acute care hospitals compared with patients with susceptible isolates.

Conclusions:

Whole-genome sequencing results showing that fluconazole-resistant C parapsilosis isolates from Georgia surveillance demonstrated low genetic diversity compared with susceptible isolates and their association with a facility network centered around 2 long-term acute care hospitals suggests clonal spread of fluconazole-resistant C parapsilosis. Further studies are needed to better understand the sudden emergence and transmission of fluconazole-resistant C parapsilosis.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos