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Urine multi-index intelligent detection based on polymer/paper hybrid microfluidic biochip for hyperuricemia monitoring.
Wang, Cuicui; Xue, Qing; Li, Haiqin; Qi, Hao; Li, Xiaochun.
Afiliación
  • Wang C; Institute of Biomedical Precision Testing and Instrumentation, College of Biomedical Engineering, Taiyuan University of Technology, Jinzhong, Shanxi, 030600, China.
  • Xue Q; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China; Academy of Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi, 030000, China.
  • Li H; Institute of Biomedical Precision Testing and Instrumentation, College of Biomedical Engineering, Taiyuan University of Technology, Jinzhong, Shanxi, 030600, China. Electronic address: lihaiqin@tyut.edu.cn.
  • Qi H; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China. Electronic address: Qi-h@163.com.
  • Li X; Institute of Biomedical Precision Testing and Instrumentation, College of Biomedical Engineering, Taiyuan University of Technology, Jinzhong, Shanxi, 030600, China. Electronic address: lixiaochun@tyut.edu.cn.
Anal Chim Acta ; 1312: 342742, 2024 Jul 11.
Article en En | MEDLINE | ID: mdl-38834261
ABSTRACT
Hyperuricemia (HUA) has gradually become a public health burden as an independent risk factor for a variety of chronic diseases. Herein, a user-friendly point-of-care (POC) detection system (namely "Smart-HUA-Monitor") based on smartphone-assisted paper-based microfluidic is proposed for colorimetric quantification of HUA urinary markers, including uric acid (UA), creatinine (CR) and pH. The detection limits of UA and CR were 0.0178 and 0.5983 mM, respectively, and the sensitivity of pH were 0.1. The method was successfully validated in artificial urine samples and 100 clinical samples. Bland-Altman plots showed a high consistency between µPAD and the testing instruments (HITACHI 7600 Automatic Analyzer, URIT-500B Urine Analyzer and AU5800B automatic biochemical analyzer) in hospital. Smart-HUA-Monitor provides an accurate quantitative, rapid, low-cost and reliable tool for the monitoring and early diagnosis of HUA urine indicators.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papel / Polímeros / Ácido Úrico / Colorimetría / Hiperuricemia Límite: Humans Idioma: En Revista: Anal Chim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papel / Polímeros / Ácido Úrico / Colorimetría / Hiperuricemia Límite: Humans Idioma: En Revista: Anal Chim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos