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Sex difference in skeletal muscle mass in relation to metabolic dysfunction-associated steatotic liver disease: a propensity score matching study.
Son, Da-Hye; Kwon, Yu-Jin; Lee, Jun-Hyuk.
Afiliación
  • Son DH; Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Kwon YJ; Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea. Electronic address: digda3@yuhs.ac.
  • Lee JH; Department of Family Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, Republic of Korea; Department of Medicine, Graduate School of Hanyang University, Seoul 04763, Republic of Korea. Electronic address: swpapa@eulji.ac.kr.
J Nutr Health Aging ; 28(6): 100270, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38833877
ABSTRACT

BACKGROUND:

While low muscle mass is considered a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), whether the relationship is independent of fat mass remains unclear.

OBJECTIVES:

This study aims to clarify the association between the sex-specific height-adjusted low skeletal muscle mass index (LSMI) and MASLD.

METHODS:

Data from the 2008-2010 Korean National Health and Nutrition Examination Survey were analyzed. LSMI was defined using the 2019 Asian Working Group for Sarcopenia. The non-alcoholic fatty liver disease-liver fat score was used to assess MASLD. Gender-specific 11 propensity score matching (PSM) was performed to mitigate the confounding effects of anthropometric variables and lifestyles. Conditional logistic analysis was used on the dataset after PSM to estimate the odds ratio (OR) with a 95% confidence interval (CI).

RESULTS:

After PSM, the prevalence of MASLD was significantly higher in men with LSMI than in those without LSMI (37.4% vs. 29.6%). No significant difference was observed in the prevalence of MASLD between groups after PSM in women (20.4% vs. 20.3%). Conditional logistic analysis revealed that the odds of having MASLD were significantly higher in men with LSMI compared to those without LSMI (OR = 1.38, 95% CI 1.09-1.75), while no significant association was found in women with LSMI (OR = 1.10, 95% CI 0.87-1.40).

CONCLUSION:

Height-adjusted LSMI is an independent factor associated with MASLD in the condition of the same level of fat mass in men. Further prospective studies in diverse populations are needed to confirm our findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encuestas Nutricionales / Músculo Esquelético / Puntaje de Propensión / Enfermedad del Hígado Graso no Alcohólico Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Nutr Health Aging Asunto de la revista: CIENCIAS DA NUTRICAO / GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encuestas Nutricionales / Músculo Esquelético / Puntaje de Propensión / Enfermedad del Hígado Graso no Alcohólico Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Nutr Health Aging Asunto de la revista: CIENCIAS DA NUTRICAO / GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Francia