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Maternal risk factors for congenital vertebral formation and mixed defects: A population-based case-control study.
Heiskanen, Susanna; Helenius, Ilkka; Syvänen, Johanna; Kemppainen, Teemu; Löyttyniemi, Eliisa; Ahonen, Matti; Gissler, Mika; Raitio, Arimatias.
Afiliación
  • Heiskanen S; Department of Paediatric Surgery and Orthopaedics, University of Turku and Turku University Hospital, Turku, Finland.
  • Helenius I; Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Syvänen J; Department of Paediatric Surgery and Orthopaedics, University of Turku and Turku University Hospital, Turku, Finland.
  • Kemppainen T; Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
  • Löyttyniemi E; Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
  • Ahonen M; Department of Paediatric Orthopaedics, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Gissler M; Knowledge Brokers, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Raitio A; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
J Child Orthop ; 18(3): 340-345, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38831858
ABSTRACT

Background:

The etiology and risk factors of congenital vertebral anomalies are mainly unclear in isolated cases. Also, there are no reports on the risk factors for different subgroups of vertebral anomalies. Therefore, we assessed and identified potential maternal risk factors for these anomalies and hypothesized that diabetes, other chronic diseases, smoking, obesity, and medication in early pregnancy would increase the risk of congenital vertebral anomalies.

Methods:

All cases with congenital vertebral anomalies were identified in the Finnish Register of Congenital Malformations from 1997 to 2016 for this nationwide register-based case-control study. Five matched controls without vertebral malformations were randomly selected. Analyzed maternal risk factors included maternal age, body mass index, parity, smoking, history of miscarriages, chronic diseases, and prescription drug purchases in early pregnancy.

Results:

The register search identified 256 cases with congenital vertebral malformations. After excluding 66 syndromic cases, 190 non-syndromic malformations (74 formation defects, 4 segmentation defects, and 112 mixed anomalies) were included in the study. Maternal smoking was a significant risk factor for formation defects (adjusted odds ratio 2.33, 95% confidence interval 1.21-4.47). Also, pregestational diabetes (adjusted odds ratio 8.53, 95% confidence interval 2.33-31.20) and rheumatoid arthritis (adjusted odds ratio 13.19, 95% confidence interval 1.31-132.95) were associated with mixed vertebral anomalies.

Conclusion:

Maternal pregestational diabetes and rheumatoid arthritis were associated with an increased risk of mixed vertebral anomalies. Maternal smoking increases the risk of formation defects and represents an avoidable risk factor for congenital scoliosis. Level of evidence III.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Child Orthop Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Child Orthop Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido