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The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer's Disease.
Tosi, Giorgia; Nigro, Salvatore; Urso, Daniele; Spinosa, Vittoria; Gnoni, Valentina; Filardi, Marco; Giaquinto, Francesco; Rizzi, Ezia; Iaia, Marika; Macchitella, Luigi; Chiarello, Ylenia; Ferrari, Federico; Angelelli, Paola; Romano, Daniele; Logroscino, Giancarlo.
Afiliación
  • Tosi G; Human and Social Sciences Department, University of Salento, Lecce 73100, Italy.
  • Nigro S; Psychology Department, University of Milano-Bicocca, Milano 20126, Italy.
  • Urso D; Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at "Pia Fondazione Cardinale G. Panico", Lecce 73039, Italy.
  • Spinosa V; Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at "Pia Fondazione Cardinale G. Panico", Lecce 73039, Italy.
  • Gnoni V; Department of Neurosciences, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London SE5 8AF, United Kingdom.
  • Filardi M; Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at "Pia Fondazione Cardinale G. Panico", Lecce 73039, Italy.
  • Giaquinto F; Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari 70121, Italy.
  • Rizzi E; Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at "Pia Fondazione Cardinale G. Panico", Lecce 73039, Italy.
  • Iaia M; Department of Neurosciences, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London SE5 8AF, United Kingdom.
  • Macchitella L; Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at "Pia Fondazione Cardinale G. Panico", Lecce 73039, Italy.
  • Chiarello Y; Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari 70121, Italy.
  • Ferrari F; Human and Social Sciences Department, University of Salento, Lecce 73100, Italy.
  • Angelelli P; Human and Social Sciences Department, University of Salento, Lecce 73100, Italy.
  • Romano D; Human and Social Sciences Department, University of Salento, Lecce 73100, Italy.
  • Logroscino G; Scientific Institute I.R.C.C.S. "E. Medea"- Unit for Severe Disabilities in Developmental Age and Young Adults (Developmental Neurology and Neurorehabilitation), Brindisi 72100, Italy.
J Neurosci ; 44(27)2024 Jul 03.
Article en En | MEDLINE | ID: mdl-38830757
ABSTRACT
It was proposed that a reorganization of the relationships between cognitive functions occurs in dementia, a vision that surpasses the idea of a mere decline of specific domains. The complexity of cognitive structure, as assessed by neuropsychological tests, can be captured by exploratory graph analysis (EGA). EGA was applied to the neuropsychological assessment of people (humans) with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease (AD; total N = 638). Both sexes were included. In AD, memory scores detach from the other cognitive functions, and memory subdomains reduce their reciprocal relation. SCD showed a pattern of segregated neuropsychological domains, and MCI showed a noisy and less stable pattern. Results suggest that AD drives a reorganization of cognitive functions toward a less-fractionated architecture compared with preclinical conditions. Cognitive functions show a reorganization that goes beyond the performance decline. Results also have clinical implications in test interpretations and usage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva / Pruebas Neuropsicológicas Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva / Pruebas Neuropsicológicas Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos