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Evaluating associations of bisphenol and phthalate exposure with time to pregnancy and subfecundity in a New York City pregnancy cohort.
Charifson, Mia; Seok, Eunsil; Wang, Yuyan; Mehta-Lee, Shilpi S; Gordon, Rachel; Liu, Mengling; Trasande, Leonardo; Kahn, Linda G.
Afiliación
  • Charifson M; Department of Population Health, New York University Grossman School of Medicine, NY, USA. Electronic address: mia.charifson@nyulangone.org.
  • Seok E; Department of Population Health, New York University Grossman School of Medicine, NY, USA.
  • Wang Y; Department of Population Health, New York University Grossman School of Medicine, NY, USA.
  • Mehta-Lee SS; Department of Obstetrics and Gynecology, New York University Langone Health, NY, USA.
  • Gordon R; Division of Environmental Medicine, New York University Grossman School of Medicine, NY, USA.
  • Liu M; Department of Population Health, New York University Grossman School of Medicine, NY, USA.
  • Trasande L; Department of Population Health, New York University Grossman School of Medicine, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, NY, USA.
  • Kahn LG; Department of Population Health, New York University Grossman School of Medicine, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, NY, USA.
Environ Pollut ; 356: 124281, 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-38830524
ABSTRACT
It is important to understand the impact of consumer chemical exposure and fecundity, a couple's measure of probability of successful conception, given approximately 15% of couples experience infertility. Prior research has generally found null associations between bisphenol and phthalate exposure and fecundability, measured via time to pregnancy (TTP). However, this research has not been updated with current chemical exposures and have often lacked diversity in their study populations. We evaluated the associations between common bisphenol and phthalate chemical exposure groups and TTP as well as subfecundity (TTP>12 months) in the New York University Children's Health Study, a diverse pregnancy cohort from 2016 onward. Using first-trimester spot-urine samples to measure chemical exposure and self-reported TTP from first-trimester questionnaires, we observed a significant adverse association between total bisphenol exposure and certain phthalate groups on TTP and odds of subfecundity. Furthermore, in a mixtures analysis to explore the joint effects of the chemical groups on the outcomes, we found evidence of a potential interaction between total bisphenol exposure and low-molecular weight phthalates on TTP. Future research should continue to update our knowledge regarding the complex and potentially interacting effects of these chemicals on reproductive health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Ácidos Ftálicos / Compuestos de Bencidrilo / Contaminantes Ambientales Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Ácidos Ftálicos / Compuestos de Bencidrilo / Contaminantes Ambientales Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido