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Neurokinin-1 Receptor Antagonism Reduces Nonallergic Ocular Redness in a Rabbit Model.
Liu, Lingjia; Wang, Shudan; Blanco, Tomas; Ge, Hongyan; Zhu, Shuyan; Yin, Jia; Chen, Yihe; Dana, Reza.
Afiliación
  • Liu L; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
  • Wang S; Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin, China.
  • Blanco T; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
  • Ge H; Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Zhu S; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
  • Yin J; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
  • Chen Y; Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Dana R; Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
J Ocul Pharmacol Ther ; 40(7): 445-451, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38829162
ABSTRACT

Purpose:

To evaluate the therapeutic efficacy of topical application of a neurokinin-1 receptor (NK1R) antagonist in a rabbit model of nonallergic ocular redness.

Methods:

Nonallergic ocular redness was induced in rabbits by a single, topical application of dapiparzole hydrochloride eye drops (0.5%, 1%, 2%, or 5%). The NK1R antagonist L-703,606 was topically applied to the eye at the same time of induction or 20 min after induction, and phosphate buffered saline (PBS) treatment served as the control. Superior bulbar conjunctival images were taken every 30 s for the first 2 min, followed by every 4 min for 8 min, and then every 10 min until 1 h. The severity of ocular redness was evaluated on the images using ImageJ-based ocular redness index (ORI) calculations.

Results:

The ORI scores were significantly increased after the application of 0.5%, 1%, 2%, or 5% dapiparzole at each time point evaluated, with the most severe redness induced by the 5% dapiprazole that led to a maximal mean increase in ORI score of 14 at 20 min post-induction and thus used for subsequent evaluation of therapeutic efficacy of NK1R antagonism. Topical L-703,606, when applied at the same time as dapiprazole induction, significantly suppressed the increase of ORI scores at all time points (∼40% decrease). Furthermore, when applied at 20 min after dapiprazole induction, L-703,606 rapidly and effectively suppressed the increase of ORI scores at 30, 40, 50, and 60 min (∼30% decrease).

Conclusions:

Topical blockade of NK1R effectively prevents and alleviates nonallergic ocular redness in a novel animal model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Animales de Enfermedad / Antagonistas del Receptor de Neuroquinina-1 Límite: Animals Idioma: En Revista: J Ocul Pharmacol Ther Asunto de la revista: FARMACOLOGIA / OFTALMOLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Animales de Enfermedad / Antagonistas del Receptor de Neuroquinina-1 Límite: Animals Idioma: En Revista: J Ocul Pharmacol Ther Asunto de la revista: FARMACOLOGIA / OFTALMOLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos