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Surgical resection due to poor outcome of the immunotherapy of a relapsed mediastinal liposarcoma: a case report.
Wang, Ming-Ji; Xu, Shu-Quan; Wu, Lei-Lei; Li, Zhi-Xin; Xie, Dong.
Afiliación
  • Wang MJ; Department of Thoracic Surgery, Fuqing City Hospital Affiliated to Fujian Medical University, Fuqing, PR China.
  • Xu SQ; School of Medicine, Tongji University, Shanghai, PR China.
  • Wu LL; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China.
  • Li ZX; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China.
  • Xie D; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China.
Future Sci OA ; 10(1): FSO906, 2024.
Article en En | MEDLINE | ID: mdl-38827794
ABSTRACT
The feasibility of surgery after immunotherapy for mediastinal liposarcoma remains uncertain. Besides, the case of immunotherapy for liposarcoma is still lacking. We report a case of recurrence after resection of a left mediastinal liposarcoma. After recurrence, one course of pembrolizumab plus anlotinib hydrochloride showed no tumor shrinkage, and genetic testing showed CDK4 amplification and PD-L1 TPS <1%; therefore, the plan was changed to one course of pembrolizumab plus palbociclib, but the tumor still did not shrink. Thus, second tumor resection was performed. In addition, the postoperative pathology was still well-differentiated liposarcoma. The significance of immunotherapy in liposarcoma still needs to be further explored. In the absence of surgical contraindications, secondary surgery might be feasible.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Future Sci OA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Future Sci OA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido