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Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging - a pilot study.
Kandukuri, Jayanth; Jain, Aseem; Karmarkar, Parag; Gadagkar, Hrishikesh; Aberman, Harold; Wang, Qihong; Rege, Abhishek.
Afiliación
  • Kandukuri J; Vasoptic Medical, Inc., Columbia, MD, USA.
  • Jain A; Vasoptic Medical, Inc., Columbia, MD, USA.
  • Karmarkar P; Vasoptic Medical, Inc., Columbia, MD, USA.
  • Gadagkar H; Vasoptic Medical, Inc., Columbia, MD, USA.
  • Aberman H; Noble Life Sciences, Inc., Sykesville, MD, USA.
  • Wang Q; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Rege A; Vasoptic Medical, Inc., Columbia, MD, USA.
Innov Surg Sci ; 9(1): 25-35, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38826630
ABSTRACT

Objectives:

Intraoperative monitoring of blood flow (BF) remains vital to guiding surgical decisions. Here, we report the use of SurgeON™ Blood Flow Monitor (BFM), a prototype system that attaches to surgical microscopes and implements laser speckle contrast imaging (LSCI) to noninvasively obtain and present vascular BF information in real-time within the microscope's eyepiece.

Methods:

The ability of SurgeON BFM to monitor BF status during reversible vascular occlusion procedures was investigated in two large animal models occlusion of saphenous veins in six NZW rabbit hindlimbs and clipping of middle cerebral artery (MCA) branches in four Dorset sheep brain hemispheres. SurgeON BFM acquired, presented, and stored LSCI-based blood flow velocity index (BFVi) data and performed indocyanine green video angiography (ICG-VA) for corroboration.

Results:

Stored BFVi data were analyzed for each phase pre-occlusion (baseline), with the vessel occluded (occlusion), and after reversal of occlusion (re-perfusion). In saphenous veins, BFVi relative to baseline reduced to 5.2±3.7 % during occlusion and returned to 102.9±14.9 % during re-perfusion. Unlike ICG-VA, SurgeON BFM was able to monitor reduced BFVi and characterize re-perfusion robustly during five serial occlusion procedures conducted 2-5 min apart on the same vessel. Across four sheep MCA vessels, BFVi reduced to 18.6±7.7 % and returned to 120.1±27.8 % of baseline during occlusion and re-perfusion phases, respectively.

Conclusions:

SurgeON BFM can noninvasively monitor vascular occlusion status and provide intuitive visualization of BF information in real-time to an operating surgeon. This technology may find application in vascular, plastic, and neurovascular surgery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Innov Surg Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Innov Surg Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania