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COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection.
Mahyuddin, Aniza P; Swa, Hannah L F; Weng, Ruifen; Zhang, Jingxian; Dhanaraj, Janice P; Sesurajan, Binny P; Rauff, Mary; Dashraath, Pradip; Kanneganti, Abhiram; Lee, Rachel; Wang, Lin-Fa; Young, Barnaby E; Tambyah, Paul A; Lye, David C; Chai, Louis Y A; Yee, Sidney; Choolani, Mahesh; Mattar, Citra N Z.
Afiliación
  • Mahyuddin AP; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Swa HLF; Diagnostics Development Hub, Agency for Science, Technology and Research, Singapore, Singapore.
  • Weng R; Diagnostics Development Hub, Agency for Science, Technology and Research, Singapore, Singapore.
  • Zhang J; Diagnostics Development Hub, Agency for Science, Technology and Research, Singapore, Singapore.
  • Dhanaraj JP; Diagnostics Development Hub, Agency for Science, Technology and Research, Singapore, Singapore.
  • Sesurajan BP; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Rauff M; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore.
  • Dashraath P; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore.
  • Kanneganti A; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore.
  • Lee R; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore.
  • Wang LF; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; The Programme for Research in Epidemic Preparedness and Response (PREPARE), National Centre for Infectious Diseases, Singapore, Singapore.
  • Young BE; The Programme for Research in Epidemic Preparedness and Response (PREPARE), National Centre for Infectious Diseases, Singapore, Singapore; National Centre for Infectious Diseases, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian Sc
  • Tambyah PA; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore.
  • Lye DC; The Programme for Research in Epidemic Preparedness and Response (PREPARE), National Centre for Infectious Diseases, Singapore, Singapore; National Centre for Infectious Diseases, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian Sc
  • Chai LYA; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore.
  • Yee S; Innovation and Enterprise, Agency for Science, Technology and Research, Connexis North Tower, Singapore, Singapore.
  • Choolani M; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore.
  • Mattar CNZ; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, National University Hospital, National University Health System, Singapore, Singapore. Electronic address: citramattar@nus.edu.
Int J Infect Dis ; 146: 107121, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38823622
ABSTRACT

OBJECTIVES:

To investigate multi-dose and timings of COVID-19 vaccines in preventing antenatal infection.

DESIGN:

Prospective observational study investigating primary vaccinations, boosters, antenatal COVID-19 infections, neutralizing antibody (Nab) durability, and cross-reactivity to Delta and Omicron variants of concern (VOCs).

RESULTS:

Ninety-eight patients completed primary vaccination prepregnancy (29.6%) and antenatally (63.3%), 24.2% of whom had antenatal COVID-19, while 7.1% were unvaccinated (28.6% had antenatal COVID-19). None had severe COVID-19. Prepregnancy vaccination resulted in vaccination-to-infection delay of 23.3 weeks, which extended to 45.2 weeks with a booster, compared to 16.9 weeks following antenatal vaccination (P < 0.001). Infections occurred at 26.2 weeks gestation in women vaccinated prepregnancy compared to 36.2 weeks gestation in those vaccinated during pregnancy (P < 0.007). The risk of COVID-19 infection was higher without antenatal vaccination (hazard ratio [HR] 14.6, P = 0.05) and after prepregnancy vaccination without a booster (HR 10.4, P = 0.002). Antenatal vaccinations initially led to high Nab levels, with mild waning but subsequent rebound. Significant Nab enhancement occurred with a third-trimester booster. Maternal-neonatal Nab transfer was efficient (transfer ratio >1), and cross-reactivity to VOCs was observed.

CONCLUSION:

Completing vaccination during any trimester delays COVID-19 infection and maintains effective neutralizing activity throughout pregnancy, with robust cross-reactivity to VOCs and efficient maternal-neonatal transfer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Inmunización Secundaria / Vacunación / Anticuerpos Neutralizantes / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Inmunización Secundaria / Vacunación / Anticuerpos Neutralizantes / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Canadá