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Transcriptomic and developmental effects of persistent organic pollutants in sentinel fishes collected near an arctic formerly used defense site.
Jordan-Ward, Renee; von Hippel, Frank A; Sancho Santos, Maria Eugenia; Wilson, Catherine A; Rodriguez Maldonado, Zyled; Dillon, Danielle; Titus, Tom; Gardell, Alison; Salamova, Amina; Postlethwait, John H; Contreras, Elise; Capozzi, Staci L; Panuwet, Parinya; Parrocha, Chelsea; Bremiller, Ruth; Guiguen, Yann; Gologergen, Jesse; Immingan, Tiffany; Miller, Pamela; Carpenter, David; Buck, C Loren.
Afiliación
  • Jordan-Ward R; Department of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ, 86011, USA.
  • von Hippel FA; Department of Community, Environment and Policy, Mel & Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., P.O. Box 245210, Tucson, AZ, 85724, USA. Electronic address: frankvonhippel@arizona.edu.
  • Sancho Santos ME; University of Arizona Health Sciences, Tucson, AZ, 85724, USA.
  • Wilson CA; Institute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR, 97403, USA.
  • Rodriguez Maldonado Z; Department of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ, 86011, USA.
  • Dillon D; Department of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ, 86011, USA.
  • Titus T; Institute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR, 97403, USA.
  • Gardell A; School of Interdisciplinary Arts and Sciences, University of Washington Tacoma, 1900 Commerce Street, Tacoma, WA, 98402, USA.
  • Salamova A; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
  • Postlethwait JH; Institute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR, 97403, USA.
  • Contreras E; Department of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ, 86011, USA.
  • Capozzi SL; O'Neill School of Public and Environmental Affairs, Indiana University, Bloomington, IN, 47405, USA.
  • Panuwet P; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
  • Parrocha C; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA.
  • Bremiller R; Institute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR, 97403, USA.
  • Guiguen Y; INRAE, LPGP, Rennes, France.
  • Gologergen J; Alaska Community Action on Toxics, 1225 E. International Airport Road, Suite 220, Anchorage, AK, 99518, USA.
  • Immingan T; Alaska Community Action on Toxics, 1225 E. International Airport Road, Suite 220, Anchorage, AK, 99518, USA.
  • Miller P; Alaska Community Action on Toxics, 1225 E. International Airport Road, Suite 220, Anchorage, AK, 99518, USA.
  • Carpenter D; Institute for Health and the Environment, University at Albany, 5 University Place, Rensselaer, NY, 12144, USA.
  • Buck CL; Department of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ, 86011, USA.
Environ Pollut ; 356: 124283, 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-38823546
ABSTRACT
Alaska contains over 600 formerly used defense (FUD) sites, many of which serve as point sources of pollution. These sites are often co-located with rural communities that depend upon traditional subsistence foods, especially lipid-rich animals that bioaccumulate and biomagnify persistent organic pollutants (POPs). Many POPs are carcinogenic and endocrine-disrupting compounds that are associated with adverse health outcomes. Therefore, elevated exposure to POPs from point sources of pollution may contribute to disproportionate incidence of disease in arctic communities. We investigated PCB concentrations and the health implications of POP exposure in sentinel fishes collected near the Northeast Cape FUD site on Sivuqaq (St. Lawrence Island), Alaska. Sivuqaq residents are almost exclusively Yupik and rely on subsistence foods. At the request of the Sivuqaq community, we examined differential gene expression and developmental pathologies associated with exposure to POPs originating at the Northeast Cape FUD site. We found significantly higher levels of PCBs in Alaska blackfish (Dallia pectoralis) collected from contaminated sites downstream of the FUD site compared to fish collected from upstream reference sites. We compared transcriptomic profiles and histopathologies of these same blackfish. Blackfish from contaminated sites overexpressed genes involved in ribosomal and FoxO signaling pathways compared to blackfish from reference sites. Contaminated blackfish also had significantly fewer thyroid follicles and smaller pigmented macrophage aggregates. Conversely, we found that ninespine stickleback (Pungitius pungitius) from contaminated sites exhibited thyroid follicle hyperplasia. Despite our previous research reporting transcriptomic and endocrine differences in stickleback from contaminated vs. reference sites, we did not find significant differences in kidney or gonadal histomorphologies. Our results demonstrate that contaminants from the Northeast Cape FUD site are associated with altered gene expression and thyroid development in native fishes. These results are consistent with our prior work demonstrating disruption of the thyroid hormone axis in Sivuqaq residents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Monitoreo del Ambiente / Transcriptoma / Peces / Contaminantes Orgánicos Persistentes Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Monitoreo del Ambiente / Transcriptoma / Peces / Contaminantes Orgánicos Persistentes Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido