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Curcumin-loaded keratin-chitosan hydrogels for enhanced peripheral nerve regeneration.
Sun, Xiguang; Huang, Xinrui; Liang, Quanduo; Wang, Nan; Zheng, Xiaotian; Zhang, Qiang; Yu, Dehai.
Afiliación
  • Sun X; Department of Hand and Podiatric Surgery, Orthopedics Center, The First Hospital of Jilin University, Jilin University, Changchun 130031, PR China.
  • Huang X; Department of Hand and Podiatric Surgery, Orthopedics Center, The First Hospital of Jilin University, Jilin University, Changchun 130031, PR China; Plastic and Burn Surgery, Children's Hospital Affiliated to Shandong University, Jinan Children's Hospital, Jinan, Shandong Province, China.
  • Liang Q; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
  • Wang N; Department of Hand and Podiatric Surgery, Orthopedics Center, The First Hospital of Jilin University, Jilin University, Changchun 130031, PR China.
  • Zheng X; Core facility of the First Hospital of Jilin University, #519 Dongminzhu Str., Changchun, Jilin 130061, PR China.
  • Zhang Q; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: qiang.zhang@ciac.ac.cn.
  • Yu D; Core facility of the First Hospital of Jilin University, #519 Dongminzhu Str., Changchun, Jilin 130061, PR China. Electronic address: yudehai@jlu.edu.cn.
Int J Biol Macromol ; 272(Pt 2): 132448, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38821302
ABSTRACT
Peripheral nerve injury often leads to symptoms of motor and sensory impairment, and slow recovery of nerves after injury and limited treatment methods will aggravate symptoms or even lead to lifelong disability. Curcumin can promote peripheral nerve regeneration, but how to accurately deliver the appropriate concentration of curcumin in the local peripheral nerve remains to be solved. In this study, we designed a human hair keratin/chitosan (C/K) hydrogel with sodium tripolyphosphate ions crosslinked to deliver curcumin topically. Chitosan improves the mechanical properties of hydrogels and keratin improves the biocompatibility of hydrogels. C/K hydrogel showed good cytocompatibility, histocompatibility and degradability. In vitro experiments showed that hydrogels can continuously release curcumin for up to 10 days. In addition, a comprehensive analysis of behavioral, electrophysiological, histology, and target organ recovery results in animal experiments showed that locally delivered curcumin can enhance nerve regeneration in addition to hydrogels. In short, we provide a new method that combines the advantages of human hair keratin, chitosan, and curcumin for nerve damage repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Curcumina / Quitosano / Queratinas / Regeneración Nerviosa Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Curcumina / Quitosano / Queratinas / Regeneración Nerviosa Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos