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GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs.
Huang, Qiutong; H J Cao, Wang; Curio, Sophie; Yu, Huiyang; Denman, Renae; Chen, Evelyn; Schreuder, Jaring; Dight, James; Chaudhry, M; Jacquelot, Nicolas; Wimmer, Verena C; Seillet, Cyril; Möröy, Tarik; Belz, Gabrielle T.
Afiliación
  • Huang Q; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • H J Cao W; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
  • Curio S; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Yu H; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
  • Denman R; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia.
  • Chen E; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Schreuder J; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Dight J; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Chaudhry M; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Jacquelot N; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Wimmer VC; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Seillet C; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Möröy T; Department of Biochemistry and Molecular Biology; Department of Microbiology, Immunology and Infectious Diseases; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.
  • Belz GT; Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Sci Immunol ; 9(95): eadj2654, 2024 May 31.
Article en En | MEDLINE | ID: mdl-38820141
ABSTRACT
Tissue-resident innate lymphoid cells (ILCs) play a vital role in the frontline defense of various tissues, including the lung. The development of type 2 ILCs (ILC2s) depends on transcription factors such as GATA3, RORα, GFI1, and Bcl11b; however, the factors regulating lung-resident ILC2s remain unclear. Through fate mapping analysis of the paralog transcription factors GFI1 and GFI1B, we show that GFI1 is consistently expressed during the transition from progenitor to mature ILC2s. In contrast, GFI1B expression is limited to specific subsets of bone marrow progenitors and lung-resident ILC progenitors. We found that GFI1B+ lung ILC progenitors represent a multi-lineage subset with tissue-resident characteristics and the potential to form lung-derived ILC subsets and liver-resident ILC1s. Loss of GFI1B in bone marrow progenitors led to the selective loss of lung-resident IL-18R+ ILCs and mature ILC2, subsequently preventing the emergence of effector ILCs that could protect the lung against inflammatory or tumor challenge.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Inmunidad Innata / Pulmón / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Sci Immunol Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Inmunidad Innata / Pulmón / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Sci Immunol Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos