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Obesity and lipid metabolism in the development of osteoporosis (Review).
Wang, Xiaochuan; Zhang, Chi; Zhao, Guang; Yang, Keda; Tao, Lin.
Afiliación
  • Wang X; Department of Orthopedics, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
  • Zhang C; Department of Orthopedics, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
  • Zhao G; Department of Orthopedics, Fourth Hospital of China Medical University, Shenyang, Liaoning 110165, P.R. China.
  • Yang K; Department of Orthopedics, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
  • Tao L; Department of Orthopedics, First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Int J Mol Med ; 54(1)2024 Jul.
Article en En | MEDLINE | ID: mdl-38818830
ABSTRACT
Osteoporosis is a common bone metabolic disease that causes a heavy social burden and seriously threatens life. Improving osteogenic capacity is necessary to correct bone mass loss in the treatment of osteoporosis. Osteoblasts are derived from the differentiation of bone marrow mesenchymal stem cells, a process that opposes adipogenic differentiation. The peroxisome proliferator­activated receptor γ and Wnt/ß­catenin signaling pathways mediate the mutual regulation of osteogenesis and adipogenesis. Lipid substances play an important role in the occurrence and development of osteoporosis. The content and proportion of lipids modulate the activity of immunocytes, mainly macrophages, and the secretion of inflammatory factors, such as IL­1, IL­6 and TNF­α. These inflammatory effectors increase the activity and promote the differentiation of osteoclasts, which leads to bone imbalance and stronger bone resorption. Obesity also decreases the activity of antioxidases and leads to oxidative stress, thereby inhibiting osteogenesis. The present review starts by examining the bidirectional differentiation of BM­MSCs, describes in detail the mechanism by which lipids affect bone metabolism, and discusses the regulatory role of inflammation and oxidative stress in this process. The review concludes that a reasonable adjustment of the content and proportion of lipids, and the alleviation of inflammatory storms and oxidative damage induced by lipid imbalances, will improve bone mass and treat osteoporosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Metabolismo de los Lípidos / Obesidad Límite: Animals / Humans Idioma: En Revista: Int J Mol Med Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Metabolismo de los Lípidos / Obesidad Límite: Animals / Humans Idioma: En Revista: Int J Mol Med Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2024 Tipo del documento: Article Pais de publicación: Grecia