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Causal association between obstructive sleep apnea and amyotrophic lateral sclerosis: a Mendelian randomization study.
Du, Rongrong; Zhu, Yahui; Chen, Peng; Li, Mao; Zhang, Ying; Huang, Xusheng.
Afiliación
  • Du R; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Zhu Y; School of Medicine, Nankai University, Tianjin, China.
  • Chen P; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Li M; Medical School of Chinese PLA, Beijing, China.
  • Zhang Y; Medical School of Chinese PLA, Beijing, China.
  • Huang X; Department of General Surgery and Institute of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Front Aging Neurosci ; 16: 1357070, 2024.
Article en En | MEDLINE | ID: mdl-38817347
ABSTRACT

Background:

Obstructive sleep apnea (OSA) had a high prevalence in the population. Whether OSA increases the risk of amyotrophic lateral sclerosis (ALS) is unknown. Our aim was to clarify this issue using two-sample Mendelian randomization (MR) analysis in a large cohort.

Methods:

Two-sample MR was used to evaluate the potential causality between OSA and ALS by selecting single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) from genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method was chosen as the primary method to estimate causal association. Weighted median, weighted mode and simple mode methods were used as sensitivity analyses to ensure the robustness of the results.

Results:

In MR analysis, IVW mode showed genetic liability to OSA was found to be significantly associated with a higher ALS risk (OR, 1.220; 95% confidence interval, 1.031-1.443; p = 0.021). No evidence of heterogeneity and horizontal pleiotropy were suggested.

Conclusion:

We found potential evidence for a causal effect of OSA on an increased risk of ALS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Aging Neurosci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Aging Neurosci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza