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Treating depression in patients with borderline personality disorder: clinical clues on the use of antidepressants.
Tomasetti, Carmine; Autullo, G; Ballerini, A; de Bartolomeis, A; Dell'Osso, B; Fiorentini, A; Tonioni, F; Villari, V; De Berardis, D.
Afiliación
  • Tomasetti C; Department of Mental Health, Alzheimer Center of Giulianova, Hospital "Maria SS dello Splendore", ASL Teramo, Giulianova (TE), Italy. carmine.tomasetti@aslteramo.it.
  • Autullo G; Psychiatry and Psychology Institute, Catholic University of Sacred Heart of Rome, Rome, Italy.
  • Ballerini A; Psychiatry Unit, Department of Health Science, University of Florence, Largo Brambilla 3, Florence, 50134, Italy.
  • de Bartolomeis A; Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Department of Neuroscience, Reproductive Science and Dentistry, University of Naples "Federico II", Naples, Italy.
  • Dell'Osso B; Department of Mental Health, Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, Milan, Italy.
  • Fiorentini A; Department of Neurosciences and Mental Health, Ca' Granda Ospedale Maggiore Policlinico, Fondazione Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), University of Milan, Milan, Italy.
  • Tonioni F; Psychiatric Emergency Service, Department of Neuroscience and Mental Health, A.O.U. "Città della Salute e della Scienza", Turin, Italy.
  • Villari V; Psychiatry and Psychology Institute, Catholic University of Sacred Heart of Rome, Rome, Italy.
  • De Berardis D; Department of Mental Health, Mental Health Center of Giulianova, ASL Teramo, Teramo, Italy.
Ann Gen Psychiatry ; 23(1): 21, 2024 May 30.
Article en En | MEDLINE | ID: mdl-38816843
ABSTRACT
Personality disorders (PD) are described as enduring patterns of markedly deviant and pervasive inner experiences and behaviors, with onset in adolescence, which lead to severe distress or impairment. Patients suffering from major depressive disorder (MDD) display higher rates of comorbidity with personality disorders, often complicating the treatment, and worsening the outcomes. Borderline personality disorder (BPD) is the most common of PD and is frequently associated with MDD, with which shares several features. The most part of research agrees on the fact that comorbid BPD in MDD patients quite doubles the poor response to treatments. Moreover, no treatment strategy stands out currently to emerge as more effective in these cases, thus urging the call for the need of new approaches. Herein, we revise the current literature on BPD, its neurobiology and comorbidity with MDD, as well as the more recent treatment strategies used. Then, based on its pharmacology, we propose a possible role of trazodone as a valuable tool to approach comorbid BPD-MDD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Gen Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Gen Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido