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Biological investigation of a novel nanocomposite based on xanthan gum-alginate hydrogel/PVA, incorporated with ZnMnFe2O4 nanoparticles.
Madfoon, Suhad Mohammed; Nile, Ruaa Shiltagh; Almajidi, Yasir Qasim; Saleh, Ebraheem Abdu Musad; Kassem, Asmaa F; Mohammed, Israa Hussein; Shafik, Shafik Shaker; Elawady, Ahmed; Singh, Rajesh; Omran, Alaa A.
Afiliación
  • Madfoon SM; Department of Pathological Analyses, University of Kufa, Al-najaf, Iraq.
  • Nile RS; Department of Pathological Analyses, University of Kufa, Al-najaf, Iraq.
  • Almajidi YQ; Baghdad College of Medical Sciences, Department of Pharmacy (Pharmaceutics), Baghdad, Iraq. Electronic address: yqasimalmajidi@gmail.com.
  • Saleh EAM; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
  • Kassem AF; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, E
  • Mohammed IH; National University of Science and Technology, Dhi Qar, Iraq.
  • Shafik SS; Experimental Nuclear Radiation Group, Scientific Research Center, Al-Ayen University, Thi-Qar, Iraq.
  • Elawady A; College of technical engineering, the Islamic University, Najaf, Iraq; College of technical engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; College of Technical Engineering, The Islamic University of Babylon, Babylon, Iraq.
  • Singh R; Department of Electronics & Communication engineering, Uttaranchal Institute of Technology, Uttaranchal University, Dehradun 248007, India.
  • Omran AA; Department of Engineering, AL-Nisour University College, Baghdad, Iraq.
Int J Biol Macromol ; 271(Pt 1): 132267, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38816292
ABSTRACT
In light of the need to create new materials that are safe for use in biomedical applications like wound healing and tissue engineering, a unique nanocomposite was formulated and produced in the current investigation. A biocompatible hydrogel was created using natural polymers xanthan gum (XG) and alginate (Alg). In order to enhance the mechanical characteristics of the natural polymer-based hydrogels, polyvinyl alcohol (PVA) was added to the hydrogel matrix. Subsequently, the XG-Alg hydrogel/PVA structure was combined with ZnMnFe2O4 nanoparticles in order to augment the antibacterial efficacy of the biomaterial. The XG-Alg hydrogel/PVA/ZnMnFe2O4 nanocomposite was analyzed using XRD, EDX, FT-IR, TGA, and FE-SEM techniques to determine its properties. In addition, the mechanical properties of the pure hydrogel were compared to those of the XG-Alg hydrogel/PVA/ZnMnFe2O4 nanocomposite. The nanocomposite exhibited a biocompatibility of 96.45 % and 94.32 % with HEK293T cell lines after 24 h and 48 h of incubation, respectively, in biological evaluations. Furthermore, a significant antibacterial efficacy was demonstrated against both gram-positive S. aureus and gram-negative E. coli bacteria. The findings suggest that the developed XG-Alg hydrogel/PVA/ZnMnFe2O4 nanocomposite has promising qualities for use in biomedical fields, such as tissue engineering.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos Bacterianos / Alcohol Polivinílico / Hidrogeles / Alginatos / Nanocompuestos / Antibacterianos Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: Irak Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos Bacterianos / Alcohol Polivinílico / Hidrogeles / Alginatos / Nanocompuestos / Antibacterianos Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: Irak Pais de publicación: Países Bajos