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Maternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons.
Laursen, Tina Quist; Ramlau-Hansen, Cecilia Høst; Tøttenborg, Sandra Søgaard; Liew, Zeyan; Toft, Gunnar; Gaml-Sørensen, Anne; Hougaard, Karin Sørig; Bonde, Jens Peter Ellekilde; Ernst, Andreas.
Afiliación
  • Laursen TQ; Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark.
  • Ramlau-Hansen CH; Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark.
  • Tøttenborg SS; Department of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Liew Z; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
  • Toft G; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
  • Gaml-Sørensen A; Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark.
  • Hougaard KS; Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; National Research Centre for the Working Environment, Copenhagen, Denmark.
  • Bonde JPE; Department of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Ernst A; Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark; Department of Urology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: aernst@ph.au.dk.
Reprod Toxicol ; 127: 108626, 2024 08.
Article en En | MEDLINE | ID: mdl-38815769
ABSTRACT
Paracetamol is suggested to have endocrine disrupting properties possibly affecting fetal programming of reproductive health that might lead to impaired semen quality and changes in reproductive hormones. In this longitudinal study, we included 1058 young adult men born 1998-2000 into the Danish National Birth Cohort with follow-up at 18-21 years of age. The exposure, maternal intake of paracetamol, was modelled in three ways dichotomized, trimester-specific, and as duration of exposure categorized into short (1-2 weeks), medium (3-9 weeks) or long duration (>9 weeks) vs. no intake. Outcomes included semen characteristics, self-measured testis volume, and reproductive hormone levels. We used negative binominal regression to estimate the percentage difference and 95% confidence interval (CI) for each outcome. In total, 547 (48%) sons were prenatally exposed to paracetamol due to maternal intake at least once. Maternal intake of paracetamol during pregnancy was not associated with any of the biomarkers in the dichotomized or trimester-specific exposure models. For duration of exposure, sons of mothers with long duration of maternal intake of paracetamol showed tendencies towards lower semen concentration (-14% [95% CI -31%; 8%]), a higher proportion of nonprogressive and immotile spermatozoa (8% [95% CI -4%; 21%]) and higher DNA Fragmentation Index (16% [95% CI -1%; 36%]) compared to son of mothers with no intake. Maternal intake of paracetamol during pregnancy was not clearly associated with biomarkers of male fecundity in adult sons. However, it cannot be ruled out that long duration of maternal intake of paracetamol might be associated with impaired semen characteristics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Biomarcadores / Analgésicos no Narcóticos / Fertilidad / Acetaminofén Límite: Adolescent / Adult / Female / Humans / Male / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Biomarcadores / Analgésicos no Narcóticos / Fertilidad / Acetaminofén Límite: Adolescent / Adult / Female / Humans / Male / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos