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A gene with a thousand alleles: The hyper-variable effectors of plant-parasitic nematodes.
Sonawala, Unnati; Beasley, Helen; Thorpe, Peter; Varypatakis, Kyriakos; Senatori, Beatrice; Jones, John T; Derevnina, Lida; Eves-van den Akker, Sebastian.
Afiliación
  • Sonawala U; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.
  • Beasley H; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.
  • Thorpe P; The Data Analysis Group, School of Life Sciences, University of Dundee, Dow St., Dundee DD1 5EH, UK.
  • Varypatakis K; Cell & Molecular Sciences Department, The James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.
  • Senatori B; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.
  • Jones JT; Cell & Molecular Sciences Department, The James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK; School of Biology, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK.
  • Derevnina L; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK.
  • Eves-van den Akker S; The Crop Science Centre, Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK. Electronic address: se389@cam.ac.uk.
Cell Genom ; 4(6): 100580, 2024 Jun 12.
Article en En | MEDLINE | ID: mdl-38815588
ABSTRACT
Pathogens are engaged in a fierce evolutionary arms race with their host. The genes at the forefront of the engagement between kingdoms are often part of diverse and highly mutable gene families. Even in this context, we discovered unprecedented variation in the hyper-variable (HYP) effectors of plant-parasitic nematodes. HYP effectors are single-gene loci that potentially harbor thousands of alleles. Alleles vary in the organization, as well as the number, of motifs within a central hyper-variable domain (HVD). We dramatically expand the HYP repertoire of two plant-parasitic nematodes and define distinct species-specific "rules" underlying the apparently flawless genetic rearrangements. Finally, by analyzing the HYPs in 68 individual nematodes, we unexpectedly found that despite the huge number of alleles, most individuals are germline homozygous. These data support a mechanism of programmed genetic variation, termed HVD editing, where alterations are locus specific, strictly governed by rules, and theoretically produce thousands of variants without errors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alelos Límite: Animals Idioma: En Revista: Cell Genom Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alelos Límite: Animals Idioma: En Revista: Cell Genom Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos