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UPLC-qTOF-MS phytochemical profile of Commiphora gileadensis leaf extract via integrated ultrasonic-microwave-assisted technique and synthesis of silver nanoparticles for enhanced antibacterial properties.
Ahmed, Hani; Zaky, Mohamed Y; M A Rashed, Marwan; Almoiliqy, Marwan; Al-Dalali, Sam; Eldin, Zienab E; Bashari, Mohanad; Cheikhyoussef, Ahmad; Alsalamah, Sulaiman A; Ibrahim Alghonaim, Mohammed; Alhudhaibi, Abdulrahman M; Wang, Jinpeng; Jiang, Li-Ping.
Afiliación
  • Ahmed H; School of Pharmaceutical Science, Nanchang University, Nanchang 330006, Jiangxi, China.
  • Zaky MY; Molecular Physiology Division, Faculty of Science, Beni-Suef University, Egypt.
  • M A Rashed M; School of Biological and Food Engineering, Suzhou University, Suzhou 234000, Anhui, China.
  • Almoiliqy M; Department of Medicine and Health Science, College of Medicine and Health Science, University of Science and Technology, Aden, Yemen.
  • Al-Dalali S; Department of Food Science and Technology, Ibb University, Ibb 70270, Yemen.
  • Eldin ZE; Molecular Physiology Division, Faculty of Science, Beni-Suef University, Egypt.
  • Bashari M; Department of Food Science and Human Nutrition, College of Applied and Health Sciences, A'Sharqiyah University, Ibra, Oman.
  • Cheikhyoussef A; Science and Technology Division, Multidisciplinary Research Centre, University of Namibia, Windhoek, Namibia.
  • Alsalamah SA; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia.
  • Ibrahim Alghonaim M; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia.
  • Alhudhaibi AM; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia.
  • Wang J; Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, Beijing, China; School of Food and Health, Beijing Technology and Business University, Beijing, China. Electronic address: jpwang@btbu.edu.cn.
  • Jiang LP; School of Pharmaceutical Science, Nanchang University, Nanchang 330006, Jiangxi, China.
Ultrason Sonochem ; 107: 106923, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38815489
ABSTRACT
The utilization of metallic nanoparticles in bio-nanofabrication holds significant potential in the field of applied research. The current study applied and compared integrated ultrasonic-microwave-assisted extraction (US/MICE), ultrasonic extraction (USE), microwave-assisted extraction (MICE), and maceration (MAE) to extract total phenolic content (TPC). In addition, the study examined the antioxidant activity of Commiphora gileadensis (Cg) leaf. The results demonstrated that the TPC of US/MICE exhibited the maximum value at 59.34 ± 0.007 mg GAE/g DM. Furthermore, at a concentration of 10 µg/mL, TPC displayed a significant scavenging effect on DPPH (56.69 %), with an EC50 (6.48 µg/mL). Comprehensive metabolite profiling of the extract using UPLC-qTOF-MS/MS was performed to identify active agents. A total of 64 chromatographic peaks were found, out of which 60 were annotated. The most prevalent classes of metabolites found were polyphenols (including flavonoids and lignans), organic compounds and their derivatives, amides and amines, terpenes, and fatty acid derivatives. Transmission electron microscopy (TEM) revealed the aggregate size of the synthesized nanoparticles and the spherical shape of C. gileadensis-mediated silver nanoparticles (Cg-AgNPs). The nanoparticles had a particle size ranging from 7.7 to 42.9 nm. The Cg-AgNPs exhibited more inhibition zones against S. aureus and E. coli. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Cg-extract, AgNPs, and Cg-AgNPs were also tested. This study demonstrated the feasibility of using combined ultrasonic-microwave-assisted extraction to separate and extract chemicals from C. gileadensis on a large scale. These compounds have potential use in the pharmaceutical industry. Combining antibacterial and biocompatible properties in materials is vital for designing new materials for biomedical applications. Additionally, the results showed that the biocompatibility of the Ag-NPs using C. gileadensis extracts demonstrated outstanding antibacterial properties.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plata / Extractos Vegetales / Hojas de la Planta / Commiphora / Nanopartículas del Metal / Ondas Ultrasónicas / Microondas / Antibacterianos Idioma: En Revista: Ultrason Sonochem Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plata / Extractos Vegetales / Hojas de la Planta / Commiphora / Nanopartículas del Metal / Ondas Ultrasónicas / Microondas / Antibacterianos Idioma: En Revista: Ultrason Sonochem Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos