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Effect and mechanism of natural composite hydrogel from fish scale intercellular matrix on diabetic chronic wound repair.
Wang, Haonan; Zhen, Zhanghe; Qin, Di; Liu, Yixuan; Liu, Ya; Chen, Xiguang.
Afiliación
  • Wang H; College of Marine Life Science, Sanya Oceanographic Institution, Ocean University of China, Qingdao 266003, China.
  • Zhen Z; Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
  • Qin D; College of Marine Life Science, Sanya Oceanographic Institution, Ocean University of China, Qingdao 266003, China.
  • Liu Y; College of Marine Life Science, Sanya Oceanographic Institution, Ocean University of China, Qingdao 266003, China.
  • Liu Y; College of Marine Life Science, Sanya Oceanographic Institution, Ocean University of China, Qingdao 266003, China.
  • Chen X; College of Marine Life Science, Sanya Oceanographic Institution, Ocean University of China, Qingdao 266003, China; Laoshan Laboratory, Qingdao 266237, China. Electronic address: xgchen@ouc.edu.cn.
Colloids Surf B Biointerfaces ; 240: 113991, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38815311
ABSTRACT
Diabetes mellitus is a chronic metabolic disease with prolonged low-grade inflammation and impaired cellular function, leading to poor wound healing. The treatment of diabetic wounds remains challenging due to the complex wound microenvironment. In view of the prominence of fish scales in traditional Chinese medicine and their wide application in modern medicine, we isolated the intercellular components in the scales of sea bass, obtained a natural composite hydrogel, fish scales gel (FSG), and applied it to diabetic chronic wounds. FSG was rich in collagen-like proteins, and possessed low-temperature gelation properties. In vitro, FSG was biocompatible and promoted fibroblast proliferation by approximately 40 %, endothelial cell migration by approximately 20 % and activated the M1 macrophages. In addition, FSG restored the function of fibroblasts and vascular endothelial cells damaged by high glucose. Importantly, FSG normalized the acute inflammatory response to impaired macrophages in a high-glucose microenvironment. Transcriptome analysis implies that this mechanism may involve enhanced cell signaling and cellular communication, improved sensitivity to cytokines, and activation of the TNF signaling pathway. Animal experiments confirmed that FSG significantly improved wound closure by approximately 15 % in diabetic rats, showing similar effects to acute wounds. In conclusion, the regulation of multiple cellular functions by FSG, especially the counterintuitive ability to induce acute inflammation, promoted diabetic wound healing and provides a novel therapeutic strategy for wound repair in diabetic patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Hidrogeles / Diabetes Mellitus Experimental Límite: Animals / Humans / Male Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Hidrogeles / Diabetes Mellitus Experimental Límite: Animals / Humans / Male Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos